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• W2934852877 endingPage "1002" @default.
• W2934852877 startingPage "995" @default.
• W2934852877 abstract "Idiopathic recurrent pregnancy loss (RPL) is a multifactorial reproductive disorder where an impaired control of apoptosis is likely involved. Triggering the cell death mechanism occurs in a spatiotemporal manner and is strongly related to a healthy pregnancy. Single nucleotide polymorphisms (SNPs) at the regulatory regions of genes are known to influence the expression patterns of apoptosis-related molecules.A total of 296 unrelated female Brazilian patients were evaluated for clinical-demographic variables and genetic factors: 140 women who had experienced an unexplained RPL (with at least two consecutive abortions) and 156 healthy multiparous women. In all patients, six SNPs were evaluated in genes of apoptosis-related pathways: FAS (rs2234767, rs1800682), FAS-L (rs763110, rs5030772), BAX (rs4645878), and BCL-2 (rs2279115) by PCR followed by a restriction fragment length polymorphism (RFLP)-based analysis.The BAX-248GA genotype is independently associated with idiopathic RPL [adjusted OR = 0.30, 95% CI 0.13-0.70, P = 0.005] susceptibility. In the same multivariate model, the variables ethnicity, smoking, and alcohol consumption were statistically associated with RPL susceptibility (P < 0.05). No association with RPL susceptibility was reported for the remaining SNPs.Our study is the first to evaluate the role of the main SNPs from both the extrinsic and intrinsic apoptosis pathways in RPL susceptibility. The association of BAX-248G/A with RPL susceptibility suggests that maternal predisposition for RPL has an essential contribution from genes involved in the delicate balance of endometrium cell turnover (cell death/proliferation). Therefore, apoptotic genes may represent promising targets for future studies on healthy pregnancies and the spectrum of pregnancy disorders." @default.
• W2934852877 created "2019-04-11" @default.
• W2934852877 creator A5015292787 @default.
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• W2934852877 date "2019-04-02" @default.
• W2934852877 modified "2023-10-16" @default.
• W2934852877 title "The role of FAS, FAS-L, BAX, and BCL-2 gene polymorphisms in determining susceptibility to unexplained recurrent pregnancy loss" @default.
• W2934852877 cites W1591552413 @default.
• W2934852877 cites W1607850601 @default.
• W2934852877 cites W1948246720 @default.
• W2934852877 cites W1969719497 @default.
• W2934852877 cites W1971873029 @default.
• W2934852877 cites W197308942 @default.
• W2934852877 cites W1973545397 @default.
• W2934852877 cites W1974460143 @default.
• W2934852877 cites W1977710038 @default.
• W2934852877 cites W1983386156 @default.
• W2934852877 cites W1987680648 @default.
• W2934852877 cites W1991892747 @default.
• W2934852877 cites W1996104439 @default.
• W2934852877 cites W2000205368 @default.
• W2934852877 cites W2004035460 @default.
• W2934852877 cites W2007230666 @default.
• W2934852877 cites W2008270848 @default.
• W2934852877 cites W2009638512 @default.
• W2934852877 cites W2010364403 @default.
• W2934852877 cites W2010967553 @default.
• W2934852877 cites W2014813076 @default.
• W2934852877 cites W2015270128 @default.
• W2934852877 cites W2030742486 @default.
• W2934852877 cites W2032860966 @default.
• W2934852877 cites W2039446949 @default.
• W2934852877 cites W2039892095 @default.
• W2934852877 cites W2042025088 @default.
• W2934852877 cites W2043665848 @default.
• W2934852877 cites W2045086385 @default.
• W2934852877 cites W2050083842 @default.
• W2934852877 cites W2055499087 @default.
• W2934852877 cites W2060580894 @default.
• W2934852877 cites W2067742560 @default.
• W2934852877 cites W2072026981 @default.
• W2934852877 cites W2073389703 @default.
• W2934852877 cites W2077933717 @default.
• W2934852877 cites W2081115770 @default.
• W2934852877 cites W2083099414 @default.
• W2934852877 cites W2088164239 @default.
• W2934852877 cites W2097704476 @default.
• W2934852877 cites W2105466569 @default.
• W2934852877 cites W2107712326 @default.
• W2934852877 cites W2112602049 @default.
• W2934852877 cites W2112901167 @default.
• W2934852877 cites W2116605828 @default.
• W2934852877 cites W2116620586 @default.
• W2934852877 cites W2120491838 @default.
• W2934852877 cites W2123133339 @default.
• W2934852877 cites W2129411519 @default.
• W2934852877 cites W2131243796 @default.
• W2934852877 cites W2131640859 @default.
• W2934852877 cites W2143487571 @default.
• W2934852877 cites W2144714391 @default.
• W2934852877 cites W2162530578 @default.
• W2934852877 cites W2163665328 @default.
• W2934852877 cites W2168674739 @default.
• W2934852877 cites W2169266667 @default.
• W2934852877 cites W2182946446 @default.
• W2934852877 cites W2414531484 @default.
• W2934852877 cites W2503170966 @default.
• W2934852877 cites W2558462124 @default.
• W2934852877 cites W2559909608 @default.
• W2934852877 cites W2752229394 @default.
• W2934852877 cites W2773004462 @default.
• W2934852877 cites W2788640168 @default.
• W2934852877 cites W2804164657 @default.
• W2934852877 cites W2883617131 @default.
• W2934852877 cites W2885752565 @default.
• W2934852877 cites W2901058926 @default.
• W2934852877 cites W4211211389 @default.
• W2934852877 cites W4238278966 @default.
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• W2934852877 doi "https://doi.org/10.1007/s10815-019-01441-w" @default.
• W2934852877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6541673" @default.
• W2934852877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30937706" @default.
• W2934852877 hasPublicationYear "2019" @default.
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