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- W2935003189 abstract "SALEN- and SALAN-based complexes with catalytically active metal centers are very promising small molecules to be utilized as part of antioxidant therapies. Here we discuss a modified SALAN-type molecule armed with two phosphonate groups that significantly increase its water solubility and aid to furnish mono- or dinuclear complexes with Cu2+ ions. The regulation of the SOD-mimicking (i.e., catalytic) disproportionation reaction of the superoxide radical anion (O2•−) at pH ~7.5 could be achieved by adjusting the metal-to-ligand stoichiometry as confirmed by McCord-Fridovich and pulse radiolysis tests. The higher antioxidant activity of the dicopper complex can be explained by the better access of O2•− to the copper centers and their more positive Cu(II)/Cu(I) redox potential. Simultaneously the analysis of in vitro effect on cells morphology indicates that cytotoxicity is also affected by the metal-to-ligand ratio, however, the active complex molecules do not show notable cytotoxicity that, together with the observed SOD-like activities, makes them potential candidates for antioxidant therapies." @default.
- W2935003189 created "2019-04-11" @default.
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- W2935003189 date "2019-06-01" @default.
- W2935003189 modified "2023-10-10" @default.
- W2935003189 title "In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand" @default.
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- W2935003189 cites W1970459421 @default.
- W2935003189 cites W1975098194 @default.
- W2935003189 cites W1975688317 @default.
- W2935003189 cites W1976502647 @default.
- W2935003189 cites W1987096917 @default.
- W2935003189 cites W1993813971 @default.
- W2935003189 cites W1997185763 @default.
- W2935003189 cites W2000887216 @default.
- W2935003189 cites W2002270654 @default.
- W2935003189 cites W2006921094 @default.
- W2935003189 cites W2008846239 @default.
- W2935003189 cites W2018746905 @default.
- W2935003189 cites W2028046413 @default.
- W2935003189 cites W2036720621 @default.
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- W2935003189 cites W2038533471 @default.
- W2935003189 cites W2042106133 @default.
- W2935003189 cites W2045236580 @default.
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- W2935003189 cites W2052999189 @default.
- W2935003189 cites W2055987225 @default.
- W2935003189 cites W2056237718 @default.
- W2935003189 cites W2058848030 @default.
- W2935003189 cites W2062866488 @default.
- W2935003189 cites W2064310079 @default.
- W2935003189 cites W2067718414 @default.
- W2935003189 cites W2072854658 @default.
- W2935003189 cites W2078509464 @default.
- W2935003189 cites W2081052344 @default.
- W2935003189 cites W2081373204 @default.
- W2935003189 cites W2086160352 @default.
- W2935003189 cites W2093220503 @default.
- W2935003189 cites W2093562926 @default.
- W2935003189 cites W2095342832 @default.
- W2935003189 cites W2100951378 @default.
- W2935003189 cites W2109903754 @default.
- W2935003189 cites W2119547517 @default.
- W2935003189 cites W2126140700 @default.
- W2935003189 cites W2137665686 @default.
- W2935003189 cites W2137941279 @default.
- W2935003189 cites W2137985245 @default.
- W2935003189 cites W2139168187 @default.
- W2935003189 cites W2143981217 @default.
- W2935003189 cites W2461577166 @default.
- W2935003189 cites W2464132643 @default.
- W2935003189 cites W2464545564 @default.
- W2935003189 cites W2512756171 @default.
- W2935003189 cites W2535730691 @default.
- W2935003189 cites W2559870612 @default.
- W2935003189 cites W2586406851 @default.
- W2935003189 cites W2758372148 @default.
- W2935003189 cites W2765658588 @default.
- W2935003189 cites W2782738009 @default.
- W2935003189 cites W2782901441 @default.
- W2935003189 cites W2786660852 @default.
- W2935003189 cites W2789815837 @default.
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- W2935003189 doi "https://doi.org/10.1016/j.cbi.2019.04.003" @default.
- W2935003189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30954465" @default.
- W2935003189 hasPublicationYear "2019" @default.
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