FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935132024> ?p ?o ?g. }

• W2935132024 endingPage "H1365" @default.
• W2935132024 startingPage "H1354" @default.
• W2935132024 abstract "Atherosclerosis is a chronic inflammatory pathology that precipitates substantial morbidity and mortality. Although initiated by physiological patterns of low and disturbed flow that differentially prime endothelial cells at sites of vessel branch points and curvature, the chronic, smoldering inflammation of atherosclerosis is accelerated by comorbidities involving inappropriate activation of the adaptive immune system, such as autoimmunity. The innate contributions to atherosclerosis, especially in the transition of monocyte to lipid-laden macrophage, are well established, but the mechanisms underpinning the infiltration, persistence, and effector dynamics of CD8 T cells in particular are not well understood. Adaptive immunity is centered on a classical cascade of antigen recognition and activation, costimulation, and effector cytokine secretion upon recall of antigen. However, chronic inflammation can generate alternative cues that supplant this behavior pattern and promote the retention and activation of peripherally activated T cells. Furthermore, the atherogenic foci that activated immune cell infiltrate are unique lipid-laden environments that offer a diverse array of stimuli, including those of survival, antigen hyporesponsiveness, and inflammatory cytokine expression. This review will focus on how known cardiovascular comorbidities may be influencing CD8 T-cell activation and how, once infiltrated within atherogenic foci, these T cells face a multitude of cues that skew the classical cascade of T-cell behavior, highlighting alternative modes of activation that may help contextualize associations of autoimmunity, viral infection, and immunotherapy with cardiovascular morbidity." @default.
• W2935132024 created "2019-04-11" @default.
• W2935132024 creator A5027034727 @default.
• W2935132024 creator A5081086263 @default.
• W2935132024 creator A5090880715 @default.
• W2935132024 date "2019-06-01" @default.
• W2935132024 modified "2023-10-09" @default.
• W2935132024 title "Activated T-effector seeds: cultivating atherosclerotic plaque through alternative activation" @default.
• W2935132024 cites W1237742250 @default.
• W2935132024 cites W1492642877 @default.
• W2935132024 cites W1506618532 @default.
• W2935132024 cites W1861425906 @default.
• W2935132024 cites W1948291240 @default.
• W2935132024 cites W1964607854 @default.
• W2935132024 cites W1967867591 @default.
• W2935132024 cites W1970450931 @default.
• W2935132024 cites W1971808794 @default.
• W2935132024 cites W1975307585 @default.
• W2935132024 cites W1981150395 @default.
• W2935132024 cites W1981298849 @default.
• W2935132024 cites W1988999016 @default.
• W2935132024 cites W1990922056 @default.
• W2935132024 cites W1991484039 @default.
• W2935132024 cites W1993746949 @default.
• W2935132024 cites W1996429292 @default.
• W2935132024 cites W1996884976 @default.
• W2935132024 cites W1997208476 @default.
• W2935132024 cites W2002301651 @default.
• W2935132024 cites W2002857708 @default.
• W2935132024 cites W2012421057 @default.
• W2935132024 cites W2013378863 @default.
• W2935132024 cites W2015484938 @default.
• W2935132024 cites W2015878901 @default.
• W2935132024 cites W2016168268 @default.
• W2935132024 cites W2019546826 @default.
• W2935132024 cites W2024803868 @default.
• W2935132024 cites W2024886564 @default.
• W2935132024 cites W2030322782 @default.
• W2935132024 cites W2034644316 @default.
• W2935132024 cites W2035396878 @default.
• W2935132024 cites W2036091970 @default.
• W2935132024 cites W2036943897 @default.
• W2935132024 cites W2040585929 @default.
• W2935132024 cites W2047925884 @default.
• W2935132024 cites W2048060421 @default.
• W2935132024 cites W2049998759 @default.
• W2935132024 cites W2054802348 @default.
• W2935132024 cites W2054864278 @default.
• W2935132024 cites W2056766110 @default.
• W2935132024 cites W2061593724 @default.
• W2935132024 cites W2062291274 @default.
• W2935132024 cites W2064756117 @default.
• W2935132024 cites W2070024133 @default.
• W2935132024 cites W2072560778 @default.
• W2935132024 cites W2078526193 @default.
• W2935132024 cites W2094941678 @default.
• W2935132024 cites W2095050873 @default.
• W2935132024 cites W2095712743 @default.
• W2935132024 cites W2096626379 @default.
• W2935132024 cites W2099939995 @default.
• W2935132024 cites W2103978206 @default.
• W2935132024 cites W2110947961 @default.
• W2935132024 cites W2111432465 @default.
• W2935132024 cites W2111897512 @default.
• W2935132024 cites W2117806308 @default.
• W2935132024 cites W2119326604 @default.
• W2935132024 cites W2121119471 @default.
• W2935132024 cites W2124894213 @default.
• W2935132024 cites W2125426464 @default.
• W2935132024 cites W2126168881 @default.
• W2935132024 cites W2126407015 @default.
• W2935132024 cites W2131273503 @default.
• W2935132024 cites W2131619138 @default.
• W2935132024 cites W2136981663 @default.
• W2935132024 cites W2140864247 @default.
• W2935132024 cites W2141913238 @default.
• W2935132024 cites W2144467686 @default.
• W2935132024 cites W2145866317 @default.
• W2935132024 cites W2147164950 @default.
• W2935132024 cites W2147340189 @default.
• W2935132024 cites W2150795824 @default.
• W2935132024 cites W2150851411 @default.
• W2935132024 cites W2151557142 @default.
• W2935132024 cites W2153185719 @default.
• W2935132024 cites W2155510706 @default.
• W2935132024 cites W2157969042 @default.
• W2935132024 cites W2159801302 @default.
• W2935132024 cites W2160427887 @default.
• W2935132024 cites W2162225087 @default.
• W2935132024 cites W2162694378 @default.
• W2935132024 cites W2165311598 @default.
• W2935132024 cites W2165779517 @default.
• W2935132024 cites W2166386384 @default.
• W2935132024 cites W2167776875 @default.
• W2935132024 cites W2168987230 @default.
• W2935132024 cites W2176542521 @default.
• W2935132024 cites W2178370458 @default.
• W2935132024 cites W2181499040 @default.

• next