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• W2935196303 abstract "Pendahuluan. Ekstrak teh hijau (senyawa polifenol/katekin) terbukti secara in vitro memiliki kemampuan sebagai antioksidan. Aktivitas fisik submaksimal merupakan salah satu penyebab peningkatan radikal bebas. Peningkatan radikal bebas dapat dideteksi dengan peningkatan MDA yaitu produk akhir dari peroksidasi lemak. Penelitian ini dilakukan untuk mengetahui efek suplementasi antioksidan ekstrak teh hijau terhadap radikal bebas yang ditimbulkan oleh aktivitas fisik submaksimal dengan mengukur kadar MDA plasma. Metode. Uji double blind control trial dilakukan pada 20 orang mahasiswa Fakultas Ilmu Olahraga Universitas Negeri Malang dengan aktivitas fisik submaksimal yaitu lari 1.500 m dalam 12 menit menggunakan mesin treadmill . Subjek terbagi atas dua kelompok: kelompok ekstrak teh hijau (Tegreen 250 mg) dan kontrol (plasebo). Suplemen diberikan satu kapsul per hari selama 14 hari sebelum aktivitas fisik submaksimal. Kadar MDA plasma diambil sebelum aktivitas submaksimal, serta 2 jam dan 48 jam setelah aktivitas fisik submaksimal.  Analisis hasil penelitian menggunakan uji ANOVA dan post hoc dengan Tukey. Penelitian telah dinilai layak secara etik oleh tim Komisi Etik Penelitian Kesehatan Fakultas Kedokteran Universitas Brawijaya. Hasil. Pada kelompok kontrol, rerata kadar MDA plasma kondisi basal, 2 jam dan 48 jam setelah aktivitas fisik submaksimal secara berturut-turut yaitu 52,43 nmol/ml (simpang baku [SB] 12,52 nmol/ml), 55,57 nmol/ml (SB 13,84 nmol/ml), dan 63,86 nmol/ml (SB 12,17 nmol/ml). Namun demikian, peningkatan tersebut tidak bermakna secara statistik (p=0,158). Pada kelompok perlakuan, terdapat penurunan kadar MDA plasma yang bermakna saat 48 jam setelah aktivitas fisik submaksimal dari kondisi basal dengan rerata kadar MDA pada basal dan 48 jam setelah aktivitas fisik submaksimal secara berturut-turut yaitu 36,14 nmol/ml (SB 5,88 nmol/ml) dan 19,86 nmol/ml (SB 8,92 nmol/ml) (p<0,001). Hasil analisis menunjukkan adanya perbedaan bermakna kadar MDA plasma antara kedua kelompok saat basal, serta 2 jam dan 48 jam setelah aktivitas fisik submaksimal dengan nilai p secara berturut-turut yaitu 0,012; <0,001, dan <0,001. Simpulan. Ekstrak teh hijau dapat menurunkan kadar MDA plasma basal, 2 jam, dan 48 jam setelah aktivitas fisik submaksimal. Kata K unci: Akti v itas fisik submaksim al, MDA, Suplementasi ekstrak teh hijau The Effect of Green Tea Extract Supplementation on Plasma Malondialdehyde (MDA) in Human with Sub-Maximal Physical Activity , Double-Blind and Placebo-Controlled Trials Introduction. Green Tea extract has been proven in vitro to have the ability as an antioxidant. Submaximal physical activity causes an increase in free radicals. The increase of MDA can detect the increase of free radicals. This study aimed to determine the effects of green tea extract supplementation against free radicals in submaximal physical activity by measuring plasma MDA. Methods. This double-blind controlled trial study was performed in 20 students of faculty of sports science with submaximal physical activity in the form of 1,500 meters running in 12 minutes using a treadmill. Subjects were divided into two groups: green tea extract group (Tegreen 250 mg) and the control group (placebo). Supplement/placebo was given as one caps a day for fourteen days before submaximal physical activity. The plasma MDA was taken before, 2 hours after, and 48 hours after the submaximal physical activity. Analysis of the results used ANOVA and post hoc Tukey. The study has been assessed by Medical Research Ethical Committee at Medical Faculty of Universitas Brawijaya. Results. In the control group, the mean value of plasma MDA levels in basal conditions, 2 hours and 48 hours after submaximal physical activity were 52.43 nmol/ml (standard deviation [SD] 12.52 nmol/ml), 55.57 nmol/ml (SD 13.84 nmol/ml), and 63.86 nmol/ml (SD 12.17 nmol/ml), respectively. However, this result was not statistically significant (p = 0.158). In the treatment group, the mean value of plasma MDA level at 48 hours after submaximal physical activity was significantly decreased compared to basal condition with mean value in basal and 48 hours after submaximal physical activity were 36.14 nmol/ml (SD 5.88 nmol/ml) and 19.86 nmol/ml (SD 8.92 nmol/ml), respectively (p <0.001). Further analysis showed a significant difference in plasma MDA levels between the two groups at basal, 2 hours, and 48 hours after submaximal physical activity (p values were 0.012; <0.001, and <0.001 respectively). Conclusion. Green tea extract can decrease the plasma level of MDA at basal, 2 hours, and 48 hours after submaximal physical activity." @default.
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• W2935196303 date "2019-03-31" @default.
• W2935196303 modified "2023-09-25" @default.
• W2935196303 title "Pengaruh Suplementasi Ekstrak Teh Hijau terhadap Kadar Malondialdehid Plasma pada Individu dengan Aktivitas Fisik Submaksimal, Double-Blind and Placebo-Controlled Trials" @default.
• W2935196303 doi "https://doi.org/10.7454/jpdi.v6i1.251" @default.
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