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- W2935316909 abstract "Gamma-delta T-cell lymphomas are very rare and aggressive T-cell neoplasms with complex heterogenicity and diagnostic complexity. Gamma-delta T lymphocytes originate from CD4− CD8− (double negative) thymocytes in the bone marrow and are distinct from alpha beta subtype. Four entities of gamma-delta lymphomas recognized by 2016 WHO classification of lymphoid neoplasms include: hepatosplenic Tγδ lymphoma (HSγδTL), primary cutaneous gamma-delta TCL (PCTCL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) and large granular lymphocytic leukemias (T-LGL). Extensive literature search based on small case series and case reports identifies few more subtypes of gamma-delta T-lymphomas which were not previously classified by World Health Organization. There remains a critical gap in our understanding of the subtypes of gamma-delta T-cell lymphomas and a lack of updated summarization. In this review, we summarize in detail on the classification, biology, heterogenicity, diagnosis, clinical behavior and treatment options of these rare but clinically important entities." @default.
- W2935316909 created "2019-04-11" @default.
- W2935316909 creator A5009218109 @default.
- W2935316909 creator A5034238598 @default.
- W2935316909 creator A5068351491 @default.
- W2935316909 date "2019-08-07" @default.
- W2935316909 modified "2023-09-30" @default.
- W2935316909 title "Gamma-Delta T-cell Lymphoma: An Overview" @default.
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- W2935316909 doi "https://doi.org/10.5772/intechopen.85542" @default.
- W2935316909 hasPublicationYear "2019" @default.
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