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• W2935397780 endingPage "924" @default.
• W2935397780 startingPage "912" @default.
• W2935397780 abstract "Human pyridoxal 5′-phosphate phosphatase (PLPP), also known as a chronophin, is a phosphatase belonging to subfamily II of the HAD phosphatases, characterized by a large cap domain. As a member of the subfamily, its cap-open conformation is expected for substrate binding. We determined apo and PLP-bound PLPP/chronophin structures showing a cap-closed conformation. The active site, in which a PLP molecule was found, is too small to accommodate a phospho-cofilin peptide, the substrate of chronophin. A conformational change to a cap-open conformation may be required for substrate binding. The core and cap domains are joined through linker peptide hinges that change conformation to open the active site. The crystal structures reveal that a disulphide bond between the cap and core domains restricts the hinge motion. The enzyme displays PLP dephosphorylation activity in the cap-closed conformation with the disulphide bond and even in the crystal state, in which repositioning of the cap and core domains is restricted. Structural analysis suggests that a small substrate such as PLP can bind to the active site through a small movement of a local motif. However, a change to the cap-open conformation is required for binding of larger substrates such as phosphopeptides to the active site." @default.
• W2935397780 created "2019-04-11" @default.
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• W2935397780 date "2019-06-01" @default.
• W2935397780 modified "2023-09-25" @default.
• W2935397780 title "Structural basis for substrate binding to human pyridoxal 5′-phosphate phosphatase/chronophin by a conformational change" @default.
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• W2935397780 doi "https://doi.org/10.1016/j.ijbiomac.2019.03.097" @default.
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