FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935567170> ?p ?o ?g. }

• W2935567170 abstract "ABSTRACT Dementia with Lewy bodies (DLB) is the second-leading degenerative dementia after Alzheimer’s disase. Neuropathologically, it is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer pathology. Neuroinflammation is increasingly recognized as a significant contributor of degeneration. Objective to examine the relationship between microglial activation as measured with [ 11 C]-PK11195 brain PET and MR diffusion tensor imaging (DTI) in DLB. Methods nineteen clinically probable DLB and 20 similarly aged controls underwent structural MRI with T1-weighted and 3T DTI sequences. Eighteen DLB subjects also underwent [ 11 C]-PK11195 PET imaging. Tract-Based Spatial Statistics (TBSS) were performed to compare DTI parameters in DLB relative to controls and identify associations of [ 11 C]-PK11195 binding with white matter integrity. Results TBSS showed widespread changes in all DTI parameters in the DLB group compared to controls (Threshold Free Cluster Enhancement (TFCE) p < 0.05). [ 11 C]-PK11195 binding in parietal cortices also correlated with widespread lower mean and radial diffusivity (TFCE p < 0.05). Conclusion Our study demonstrates that higher PK11195 binding is associated with a relative preservation of white matter, positioning neuroinflammation as a potential early marker in the DLB pathogenic cascade." @default.
• W2935567170 created "2019-04-11" @default.
• W2935567170 creator A5000198684 @default.
• W2935567170 creator A5025003387 @default.
• W2935567170 creator A5031935895 @default.
• W2935567170 creator A5034431716 @default.
• W2935567170 creator A5051840780 @default.
• W2935567170 creator A5053485967 @default.
• W2935567170 creator A5055137253 @default.
• W2935567170 creator A5064571229 @default.
• W2935567170 creator A5073631171 @default.
• W2935567170 creator A5089779357 @default.
• W2935567170 creator A5091579352 @default.
• W2935567170 date "2019-04-09" @default.
• W2935567170 modified "2023-09-23" @default.
• W2935567170 title "Correlation of Microglial Activation with White Matter Changes in Dementia with Lewy Bodies" @default.
• W2935567170 cites W1527671059 @default.
• W2935567170 cites W1820933137 @default.
• W2935567170 cites W1997419117 @default.
• W2935567170 cites W2006096283 @default.
• W2935567170 cites W2010617611 @default.
• W2935567170 cites W2019305871 @default.
• W2935567170 cites W2025047388 @default.
• W2935567170 cites W2030773481 @default.
• W2935567170 cites W2044488773 @default.
• W2935567170 cites W2044614452 @default.
• W2935567170 cites W2044663741 @default.
• W2935567170 cites W2045347306 @default.
• W2935567170 cites W2046557060 @default.
• W2935567170 cites W2055635555 @default.
• W2935567170 cites W2073673434 @default.
• W2935567170 cites W2076903330 @default.
• W2935567170 cites W2101135654 @default.
• W2935567170 cites W2102572922 @default.
• W2935567170 cites W2137226568 @default.
• W2935567170 cites W2138790588 @default.
• W2935567170 cites W2157035009 @default.
• W2935567170 cites W2171127842 @default.
• W2935567170 cites W2222652062 @default.
• W2935567170 cites W2298656843 @default.
• W2935567170 cites W2569419696 @default.
• W2935567170 cites W2623521763 @default.
• W2935567170 cites W2724559439 @default.
• W2935567170 cites W2799640243 @default.
• W2935567170 cites W2900321422 @default.
• W2935567170 cites W2915982396 @default.
• W2935567170 doi "https://doi.org/10.1101/599241" @default.
• W2935567170 hasPublicationYear "2019" @default.
• W2935567170 type Work @default.
• W2935567170 sameAs 2935567170 @default.
• W2935567170 citedByCount "0" @default.
• W2935567170 crossrefType "posted-content" @default.
• W2935567170 hasAuthorship W2935567170A5000198684 @default.
• W2935567170 hasAuthorship W2935567170A5025003387 @default.
• W2935567170 hasAuthorship W2935567170A5031935895 @default.
• W2935567170 hasAuthorship W2935567170A5034431716 @default.
• W2935567170 hasAuthorship W2935567170A5051840780 @default.
• W2935567170 hasAuthorship W2935567170A5053485967 @default.
• W2935567170 hasAuthorship W2935567170A5055137253 @default.
• W2935567170 hasAuthorship W2935567170A5064571229 @default.
• W2935567170 hasAuthorship W2935567170A5073631171 @default.
• W2935567170 hasAuthorship W2935567170A5089779357 @default.
• W2935567170 hasAuthorship W2935567170A5091579352 @default.
• W2935567170 hasBestOaLocation W29355671701 @default.
• W2935567170 hasConcept C126322002 @default.
• W2935567170 hasConcept C126838900 @default.
• W2935567170 hasConcept C142724271 @default.
• W2935567170 hasConcept C143409427 @default.
• W2935567170 hasConcept C149550507 @default.
• W2935567170 hasConcept C15744967 @default.
• W2935567170 hasConcept C164705383 @default.
• W2935567170 hasConcept C169760540 @default.
• W2935567170 hasConcept C2778548049 @default.
• W2935567170 hasConcept C2779134260 @default.
• W2935567170 hasConcept C2779483572 @default.
• W2935567170 hasConcept C2781192897 @default.
• W2935567170 hasConcept C2989005 @default.
• W2935567170 hasConcept C71924100 @default.
• W2935567170 hasConcept C87753298 @default.
• W2935567170 hasConceptScore W2935567170C126322002 @default.
• W2935567170 hasConceptScore W2935567170C126838900 @default.
• W2935567170 hasConceptScore W2935567170C142724271 @default.
• W2935567170 hasConceptScore W2935567170C143409427 @default.
• W2935567170 hasConceptScore W2935567170C149550507 @default.
• W2935567170 hasConceptScore W2935567170C15744967 @default.
• W2935567170 hasConceptScore W2935567170C164705383 @default.
• W2935567170 hasConceptScore W2935567170C169760540 @default.
• W2935567170 hasConceptScore W2935567170C2778548049 @default.
• W2935567170 hasConceptScore W2935567170C2779134260 @default.
• W2935567170 hasConceptScore W2935567170C2779483572 @default.
• W2935567170 hasConceptScore W2935567170C2781192897 @default.
• W2935567170 hasConceptScore W2935567170C2989005 @default.
• W2935567170 hasConceptScore W2935567170C71924100 @default.
• W2935567170 hasConceptScore W2935567170C87753298 @default.
• W2935567170 hasLocation W29355671701 @default.
• W2935567170 hasLocation W29355671702 @default.
• W2935567170 hasLocation W29355671703 @default.
• W2935567170 hasLocation W29355671704 @default.
• W2935567170 hasLocation W29355671705 @default.
• W2935567170 hasOpenAccess W2935567170 @default.

• next