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• W2935581598 startingPage "1934578X1300800" @default.
• W2935581598 abstract "Alkaloid extracts of eleven Narcissus (Amaryllidaceae) species and varieties were studied with respect to their acetylcholinesterase (HuAChE) and butyrylcholinesterase (HuBuChE) inhibitory activity and alkaloid patterns. Forty-two alkaloids were determined by GC/MS, and thirty of them identified from their mass spectra, retention times and retention indexes. Promising HuAChE inhibition activity was demonstrated by nine Narcissus taxa and HuBuChE inhibition by Narcissus poeticus cv. Pink Parasol with an IC 50 value of 3.3 ± 0.5 μg/mL. The alkaloid identified as (11C- S)-homolycorine was isolated in pure form from Narcissus Sir W. Churchill using preparative TLC and was tested for its biological activity. Homolycorine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC 50 values of 63.7±4.3 μM and 151.0±15.2 μM, respectively." @default.
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• W2935581598 date "2013-06-01" @default.
• W2935581598 modified "2023-10-01" @default.
• W2935581598 title "Isolation and Cholinesterase Inhibitory Activity of <i>Narcissus</i> Extracts and Amaryllidaceae Alkaloid" @default.
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• W2935581598 doi "https://doi.org/10.1177/1934578x1300800625" @default.
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