FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935715926> ?p ?o ?g. }

• W2935715926 endingPage "147" @default.
• W2935715926 startingPage "138" @default.
• W2935715926 abstract "Abstract Recurrent miscarriage (RM) is characterized by two or more consecutive losses of a clinically established intrauterine pregnancy at early gestation. To date, the etiology of RM remains poorly understood. Impaired decidualization is thought to predispose women to subsequent pregnancy failure. The transcriptional factor brain and muscle aryl hydrocarbon receptor nuclear translocator-like (BMAL1) controls circadian rhythms and regulates a very large diversity of physiological processes. BMAL1 is essential for fertility. Here, we investigated the expression and function of BMAL1 in human decidualization and its relation with RM. A total of 39 decidua samples were collected. We also examined human endometrial stromal cells (HESCs) and primary endometrial stromal cells (ESCs), and primary decidual stromal cells (DSCs) isolated from decidua of first-trimester pregnancies. Compared to normal pregnant women, the expression of BMAL1 was reduced in the decidual tissues from individuals with RM. After in vitro induction of decidualization, the transcription of BMAL1 in both HESCs and primary ESCs was increased. This is in line with the relatively higher expression of BMAL1 in DSCs than in ESCs. Silencing of BMAL1 resulted in impaired decidualization. Moreover, levels of tissue inhibitors of metalloproteinases (TIMPs) increased significantly upon decidualization. Further experiments demonstrated that BMAL1 silencing curtails the ability of DSCs to restrict excessive trophoblast invasion via downregulation of TIMP3. Our study demonstrates a functional role for BMAL1 during decidualization: the downregulation of BMAL1 in RM leads to impaired decidualization and aberrant trophoblast invasion by regulating TIMP3 and consequently predisposing individuals for RM." @default.
• W2935715926 created "2019-04-25" @default.
• W2935715926 creator A5000666528 @default.
• W2935715926 creator A5060667885 @default.
• W2935715926 creator A5061015930 @default.
• W2935715926 creator A5074734978 @default.
• W2935715926 creator A5077350590 @default.
• W2935715926 creator A5090728786 @default.
• W2935715926 date "2019-04-15" @default.
• W2935715926 modified "2023-10-18" @default.
• W2935715926 title "Impaired decidualization caused by downregulation of circadian clock gene BMAL1 contributes to human recurrent miscarriage†" @default.
• W2935715926 cites W1523156071 @default.
• W2935715926 cites W1965341846 @default.
• W2935715926 cites W1967120925 @default.
• W2935715926 cites W1972766975 @default.
• W2935715926 cites W1979277919 @default.
• W2935715926 cites W1992669445 @default.
• W2935715926 cites W2000789149 @default.
• W2935715926 cites W2013244539 @default.
• W2935715926 cites W2017861276 @default.
• W2935715926 cites W2027082600 @default.
• W2935715926 cites W2037104566 @default.
• W2935715926 cites W2049014099 @default.
• W2935715926 cites W2065346340 @default.
• W2935715926 cites W2069663899 @default.
• W2935715926 cites W2078569168 @default.
• W2935715926 cites W2081094746 @default.
• W2935715926 cites W2081323362 @default.
• W2935715926 cites W2089509408 @default.
• W2935715926 cites W2099083365 @default.
• W2935715926 cites W2099354813 @default.
• W2935715926 cites W2103183894 @default.
• W2935715926 cites W2117371378 @default.
• W2935715926 cites W2119975890 @default.
• W2935715926 cites W2121847288 @default.
• W2935715926 cites W2127365820 @default.
• W2935715926 cites W2137414245 @default.
• W2935715926 cites W2145444991 @default.
• W2935715926 cites W2147007332 @default.
• W2935715926 cites W2149280896 @default.
• W2935715926 cites W2152689989 @default.
• W2935715926 cites W2153354406 @default.
• W2935715926 cites W2154856535 @default.
• W2935715926 cites W2155916998 @default.
• W2935715926 cites W2176587076 @default.
• W2935715926 cites W2222113668 @default.
• W2935715926 cites W2232816331 @default.
• W2935715926 cites W2480308563 @default.
• W2935715926 cites W2605612456 @default.
• W2935715926 cites W2614898738 @default.
• W2935715926 cites W2781215760 @default.
• W2935715926 cites W2788087111 @default.
• W2935715926 cites W2792346637 @default.
• W2935715926 cites W4211211389 @default.
• W2935715926 cites W4253353642 @default.
• W2935715926 doi "https://doi.org/10.1093/biolre/ioz063" @default.
• W2935715926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30985884" @default.
• W2935715926 hasPublicationYear "2019" @default.
• W2935715926 type Work @default.
• W2935715926 sameAs 2935715926 @default.
• W2935715926 citedByCount "23" @default.
• W2935715926 countsByYear W29357159262020 @default.
• W2935715926 countsByYear W29357159262021 @default.
• W2935715926 countsByYear W29357159262022 @default.
• W2935715926 countsByYear W29357159262023 @default.
• W2935715926 crossrefType "journal-article" @default.
• W2935715926 hasAuthorship W2935715926A5000666528 @default.
• W2935715926 hasAuthorship W2935715926A5060667885 @default.
• W2935715926 hasAuthorship W2935715926A5061015930 @default.
• W2935715926 hasAuthorship W2935715926A5074734978 @default.
• W2935715926 hasAuthorship W2935715926A5077350590 @default.
• W2935715926 hasAuthorship W2935715926A5090728786 @default.
• W2935715926 hasConcept C104317684 @default.
• W2935715926 hasConcept C119056186 @default.
• W2935715926 hasConcept C126322002 @default.
• W2935715926 hasConcept C127561419 @default.
• W2935715926 hasConcept C134018914 @default.
• W2935715926 hasConcept C16685009 @default.
• W2935715926 hasConcept C16930146 @default.
• W2935715926 hasConcept C172680121 @default.
• W2935715926 hasConcept C2776953305 @default.
• W2935715926 hasConcept C2777495146 @default.
• W2935715926 hasConcept C2778316770 @default.
• W2935715926 hasConcept C2779234561 @default.
• W2935715926 hasConcept C2780197806 @default.
• W2935715926 hasConcept C2781107390 @default.
• W2935715926 hasConcept C502942594 @default.
• W2935715926 hasConcept C54355233 @default.
• W2935715926 hasConcept C71924100 @default.
• W2935715926 hasConcept C86803240 @default.
• W2935715926 hasConcept C95444343 @default.
• W2935715926 hasConceptScore W2935715926C104317684 @default.
• W2935715926 hasConceptScore W2935715926C119056186 @default.
• W2935715926 hasConceptScore W2935715926C126322002 @default.
• W2935715926 hasConceptScore W2935715926C127561419 @default.
• W2935715926 hasConceptScore W2935715926C134018914 @default.
• W2935715926 hasConceptScore W2935715926C16685009 @default.
• W2935715926 hasConceptScore W2935715926C16930146 @default.

• next