FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935726677> ?p ?o ?g. }

• W2935726677 endingPage "321" @default.
• W2935726677 startingPage "308" @default.
• W2935726677 abstract "Candida albicans is a commensal fungus that associates with human hosts. Under normal circumstances this interaction does not produce any severe life-threatening disease, as macrophages of the innate immune system will result in its clearance. However, disorders may arise in immunosuppressed individuals. To understand the bioactivity of Candida albicans cell wall polysaccharides, which represent an important component of its function, mannoprotein from this fungus was extracted, purified and analyzed. Mannoprotein with α-(1,2) and α-(1,6) linkages was investigated with use of HPLC and NMR. Co-incubation of mannoprotein with macrophages resulted in a mannoprotein with the potential to polarize macrophages to M1 and promote phagocytosis/microbial killing ability thus increasing the clearance of pathogens through Akt2. Moreover, mannoprotein within the cell wall promoted cell proliferation and inhibited apoptosis by activation of the Akt signaling pathway. Collectively, α-(1,6)(1,2)-mannoprotein, one of the five polysaccharides extracted from the cell wall of Candida albicans, demonstrates immune-enhancing effects by activation of the Akt signaling pathway. These findings provide important new insights into the biological effects of polysaccharides on macrophages. Such information can then serve as the foundation for the development of novel anti-fungal medications." @default.
• W2935726677 created "2019-04-25" @default.
• W2935726677 creator A5005360514 @default.
• W2935726677 creator A5013861025 @default.
• W2935726677 creator A5039214243 @default.
• W2935726677 creator A5053095778 @default.
• W2935726677 creator A5072516184 @default.
• W2935726677 creator A5080744549 @default.
• W2935726677 date "2019-07-01" @default.
• W2935726677 modified "2023-10-12" @default.
• W2935726677 title "Cell wall mannoprotein of Candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the Akt signal pathway" @default.
• W2935726677 cites W1521769145 @default.
• W2935726677 cites W1577845999 @default.
• W2935726677 cites W1893975780 @default.
• W2935726677 cites W1981056356 @default.
• W2935726677 cites W1990933524 @default.
• W2935726677 cites W2022820366 @default.
• W2935726677 cites W2024755223 @default.
• W2935726677 cites W2031701891 @default.
• W2935726677 cites W2050910224 @default.
• W2935726677 cites W2056450591 @default.
• W2935726677 cites W2069765131 @default.
• W2935726677 cites W2078444779 @default.
• W2935726677 cites W2080464858 @default.
• W2935726677 cites W2082390177 @default.
• W2935726677 cites W2085601672 @default.
• W2935726677 cites W2101984662 @default.
• W2935726677 cites W2111946566 @default.
• W2935726677 cites W2149714948 @default.
• W2935726677 cites W2153496184 @default.
• W2935726677 cites W2171581152 @default.
• W2935726677 cites W2180985314 @default.
• W2935726677 cites W2272191942 @default.
• W2935726677 cites W2413230319 @default.
• W2935726677 cites W2528538840 @default.
• W2935726677 cites W2547462842 @default.
• W2935726677 cites W2582254624 @default.
• W2935726677 cites W2582393724 @default.
• W2935726677 cites W2592724829 @default.
• W2935726677 cites W2734612248 @default.
• W2935726677 cites W2741409856 @default.
• W2935726677 cites W2766341599 @default.
• W2935726677 cites W2768271583 @default.
• W2935726677 cites W2790823487 @default.
• W2935726677 cites W2793374150 @default.
• W2935726677 cites W2794084078 @default.
• W2935726677 cites W2794422589 @default.
• W2935726677 cites W2796014251 @default.
• W2935726677 cites W4211087629 @default.
• W2935726677 doi "https://doi.org/10.1016/j.intimp.2019.03.032" @default.
• W2935726677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31005041" @default.
• W2935726677 hasPublicationYear "2019" @default.
• W2935726677 type Work @default.
• W2935726677 sameAs 2935726677 @default.
• W2935726677 citedByCount "12" @default.
• W2935726677 countsByYear W29357266772020 @default.
• W2935726677 countsByYear W29357266772021 @default.
• W2935726677 countsByYear W29357266772022 @default.
• W2935726677 countsByYear W29357266772023 @default.
• W2935726677 crossrefType "journal-article" @default.
• W2935726677 hasAuthorship W2935726677A5005360514 @default.
• W2935726677 hasAuthorship W2935726677A5013861025 @default.
• W2935726677 hasAuthorship W2935726677A5039214243 @default.
• W2935726677 hasAuthorship W2935726677A5053095778 @default.
• W2935726677 hasAuthorship W2935726677A5072516184 @default.
• W2935726677 hasAuthorship W2935726677A5080744549 @default.
• W2935726677 hasConcept C100817775 @default.
• W2935726677 hasConcept C125235067 @default.
• W2935726677 hasConcept C136449434 @default.
• W2935726677 hasConcept C1491633281 @default.
• W2935726677 hasConcept C160448771 @default.
• W2935726677 hasConcept C185592680 @default.
• W2935726677 hasConcept C190283241 @default.
• W2935726677 hasConcept C203014093 @default.
• W2935726677 hasConcept C2780917455 @default.
• W2935726677 hasConcept C55493867 @default.
• W2935726677 hasConcept C62478195 @default.
• W2935726677 hasConcept C75217442 @default.
• W2935726677 hasConcept C86803240 @default.
• W2935726677 hasConcept C8891405 @default.
• W2935726677 hasConcept C89423630 @default.
• W2935726677 hasConcept C95444343 @default.
• W2935726677 hasConceptScore W2935726677C100817775 @default.
• W2935726677 hasConceptScore W2935726677C125235067 @default.
• W2935726677 hasConceptScore W2935726677C136449434 @default.
• W2935726677 hasConceptScore W2935726677C1491633281 @default.
• W2935726677 hasConceptScore W2935726677C160448771 @default.
• W2935726677 hasConceptScore W2935726677C185592680 @default.
• W2935726677 hasConceptScore W2935726677C190283241 @default.
• W2935726677 hasConceptScore W2935726677C203014093 @default.
• W2935726677 hasConceptScore W2935726677C2780917455 @default.
• W2935726677 hasConceptScore W2935726677C55493867 @default.
• W2935726677 hasConceptScore W2935726677C62478195 @default.
• W2935726677 hasConceptScore W2935726677C75217442 @default.
• W2935726677 hasConceptScore W2935726677C86803240 @default.
• W2935726677 hasConceptScore W2935726677C8891405 @default.
• W2935726677 hasConceptScore W2935726677C89423630 @default.
• W2935726677 hasConceptScore W2935726677C95444343 @default.

• next