FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935777905> ?p ?o ?g. }

• W2935777905 endingPage "359" @default.
• W2935777905 startingPage "353" @default.
• W2935777905 abstract "Objective: This study aimed to investigate the etiology and pathology of preeclampsia (PE), a two-stage disorder involving uteroplacental dysfunction resulting from abnormal implantation and placentation, and gestational hypertension (GH), for which maternal organic vascular disorder is often an underlying factor.Methods: We assessed concentrations of oxygen free radicals (d-ROMs), maternal angiogenic factor (PlGF), and antiangiogenic factor (sFlt-1), placental hypoxic changes, oxidative DNA damage, and maternal organic vascular disorders in 23 women with PE (PE group), 13 with GH (GH group), and 16 with uncomplicated pregnancies (normal group). Intima-media thickness (IMT) of the carotid artery was assessed as a proxy for maternal organ vascular disorder. Immunohistochemical analysis was performed to measure the proportion of placental trophoblast cell nuclei staining positive for hypoxia-inducible factor-1α (HIF-1α), which reflects hypoxic changes, and 8-hydroxy-2′-deoxyguanosine (8-OHdG), which reflects oxidative DNA damage.Results: Maternal serum d-ROM concentrations were significantly increased in both GH and PE groups relative to the normal group. Maternal serum d-ROM concentrations were significantly increased in both GH and PE groups relative to the normal group. Maternal serum sFlt-1 concentrations, ratio of sFlt-1/PlGF, and proportions of HIF-1α-positive nuclei and 8-OHdG-positive nuclei were significantly higher in the PE group compared to GH and normal groups. IMT was significantly greater in GH and PE groups compared to the normal group, and was higher in the GH group compared to the PE group.Conclusions: Our findings suggest that placental hypoxic changes and oxidative DNA damage are severe in patients with PE and accompanied by an increase in antiangiogenic factors. Moreover, maternal organ vascular disorder was more severe in patients with GH compared to those with PE, as assessed by IMT.Key message: PE is a two-stage disorder that involves uteroplacental dysfunction, and organic vascular disorder underlies GH." @default.
• W2935777905 created "2019-04-25" @default.
• W2935777905 creator A5021398823 @default.
• W2935777905 creator A5029470681 @default.
• W2935777905 creator A5034365422 @default.
• W2935777905 creator A5042683248 @default.
• W2935777905 creator A5046802203 @default.
• W2935777905 creator A5049590666 @default.
• W2935777905 date "2019-05-02" @default.
• W2935777905 modified "2023-09-27" @default.
• W2935777905 title "Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia" @default.
• W2935777905 cites W1969408542 @default.
• W2935777905 cites W1976868429 @default.
• W2935777905 cites W1991249208 @default.
• W2935777905 cites W2009509729 @default.
• W2935777905 cites W2009522838 @default.
• W2935777905 cites W2028430421 @default.
• W2935777905 cites W2036469757 @default.
• W2935777905 cites W2059277748 @default.
• W2935777905 cites W2072756039 @default.
• W2935777905 cites W2087110921 @default.
• W2935777905 cites W2095658258 @default.
• W2935777905 cites W2156191298 @default.
• W2935777905 cites W2164953175 @default.
• W2935777905 cites W2604301321 @default.
• W2935777905 cites W2793594342 @default.
• W2935777905 cites W2914787585 @default.
• W2935777905 cites W3022285062 @default.
• W2935777905 doi "https://doi.org/10.1080/14767058.2019.1608175" @default.
• W2935777905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30983440" @default.
• W2935777905 hasPublicationYear "2019" @default.
• W2935777905 type Work @default.
• W2935777905 sameAs 2935777905 @default.
• W2935777905 citedByCount "11" @default.
• W2935777905 countsByYear W29357779052019 @default.
• W2935777905 countsByYear W29357779052020 @default.
• W2935777905 countsByYear W29357779052021 @default.
• W2935777905 countsByYear W29357779052022 @default.
• W2935777905 countsByYear W29357779052023 @default.
• W2935777905 crossrefType "journal-article" @default.
• W2935777905 hasAuthorship W2935777905A5021398823 @default.
• W2935777905 hasAuthorship W2935777905A5029470681 @default.
• W2935777905 hasAuthorship W2935777905A5034365422 @default.
• W2935777905 hasAuthorship W2935777905A5042683248 @default.
• W2935777905 hasAuthorship W2935777905A5046802203 @default.
• W2935777905 hasAuthorship W2935777905A5049590666 @default.
• W2935777905 hasConcept C126322002 @default.
• W2935777905 hasConcept C134018914 @default.
• W2935777905 hasConcept C167734588 @default.
• W2935777905 hasConcept C172680121 @default.
• W2935777905 hasConcept C178790620 @default.
• W2935777905 hasConcept C185592680 @default.
• W2935777905 hasConcept C2776953305 @default.
• W2935777905 hasConcept C2777025900 @default.
• W2935777905 hasConcept C2777218350 @default.
• W2935777905 hasConcept C2777583542 @default.
• W2935777905 hasConcept C2778376644 @default.
• W2935777905 hasConcept C2779234561 @default.
• W2935777905 hasConcept C2780972559 @default.
• W2935777905 hasConcept C46973012 @default.
• W2935777905 hasConcept C540031477 @default.
• W2935777905 hasConcept C54355233 @default.
• W2935777905 hasConcept C71924100 @default.
• W2935777905 hasConcept C7836513 @default.
• W2935777905 hasConcept C86803240 @default.
• W2935777905 hasConceptScore W2935777905C126322002 @default.
• W2935777905 hasConceptScore W2935777905C134018914 @default.
• W2935777905 hasConceptScore W2935777905C167734588 @default.
• W2935777905 hasConceptScore W2935777905C172680121 @default.
• W2935777905 hasConceptScore W2935777905C178790620 @default.
• W2935777905 hasConceptScore W2935777905C185592680 @default.
• W2935777905 hasConceptScore W2935777905C2776953305 @default.
• W2935777905 hasConceptScore W2935777905C2777025900 @default.
• W2935777905 hasConceptScore W2935777905C2777218350 @default.
• W2935777905 hasConceptScore W2935777905C2777583542 @default.
• W2935777905 hasConceptScore W2935777905C2778376644 @default.
• W2935777905 hasConceptScore W2935777905C2779234561 @default.
• W2935777905 hasConceptScore W2935777905C2780972559 @default.
• W2935777905 hasConceptScore W2935777905C46973012 @default.
• W2935777905 hasConceptScore W2935777905C540031477 @default.
• W2935777905 hasConceptScore W2935777905C54355233 @default.
• W2935777905 hasConceptScore W2935777905C71924100 @default.
• W2935777905 hasConceptScore W2935777905C7836513 @default.
• W2935777905 hasConceptScore W2935777905C86803240 @default.
• W2935777905 hasIssue "3" @default.
• W2935777905 hasLocation W29357779051 @default.
• W2935777905 hasOpenAccess W2935777905 @default.
• W2935777905 hasPrimaryLocation W29357779051 @default.
• W2935777905 hasRelatedWork W1993795923 @default.
• W2935777905 hasRelatedWork W1997526440 @default.
• W2935777905 hasRelatedWork W2018480122 @default.
• W2935777905 hasRelatedWork W2039466440 @default.
• W2935777905 hasRelatedWork W2131811784 @default.
• W2935777905 hasRelatedWork W2141521254 @default.
• W2935777905 hasRelatedWork W3037532943 @default.
• W2935777905 hasRelatedWork W4244773948 @default.
• W2935777905 hasRelatedWork W4309419172 @default.
• W2935777905 hasRelatedWork W2156499933 @default.

• next