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- W2935778057 abstract "A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a could effectively inhibit PTP1B with an IC50 value of 0.63 μM accompanied with high selectivity ratio (9.5-fold) over T-cell protein tyrosine phosphatase (TCPTP). This compound is cell permeable with relatively low cytotoxicity. The high binding affinity and selectivity was disclosed by molecular modeling and dynamics studies. The structural features essential for activity were confirmed by quantum chemical studies." @default.
- W2935778057 created "2019-04-25" @default.
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- W2935778057 date "2019-07-01" @default.
- W2935778057 modified "2023-10-16" @default.
- W2935778057 title "Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase" @default.
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- W2935778057 doi "https://doi.org/10.1016/j.bioorg.2019.03.074" @default.
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