Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935779079> ?p ?o ?g. }
- W2935779079 abstract "Since acyclovir and its derivatives were launched for herpesviruses control almost four decades ago, the search for novel antivirals has waned. However, as human life expectancy has increased, so has the number of immunocompromised individuals who receive prolonged treatment for HSV recurrences. This has led to an increase in unresponsive patients due to acquired viral drug resistance. Thus, novel treatments need to be explored. Here we explored the HSV-1 ICP0 E3 ligase as a potential antiviral target because (i) ICP0 is expressed before virus replication, (ii) it is essential for infection in vivo , (iii) it is required for efficient reactivation of the virus from latency, (iv) inhibition of its E3 ligase activity would sustain host immune responses, and (v) it is shared by other herpesviruses. We report a compound that inhibits HSV-1 infection in an ICP0-dependent manner by inhibiting ICP0 E3 ligase activity." @default.
- W2935779079 created "2019-04-25" @default.
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- W2935779079 date "2019-07-01" @default.
- W2935779079 modified "2023-10-13" @default.
- W2935779079 title "Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an <i>In Vitro</i> High-Throughput Screening Assay" @default.
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- W2935779079 doi "https://doi.org/10.1128/jvi.00619-19" @default.
- W2935779079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580980" @default.
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- W2935779079 hasPublicationYear "2019" @default.
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