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- W2935862224 abstract "Background: In Marfan Syndrome (MFS), aortic dilatation is one of the main cardiovascular manifestations which deteriorate due to the physiological changes during pregnancy. We aimed to assess the up-to-date management and outcomes of aortic root dilation and dissection (AoD) in pregnancy with MFS. Patients and Methods: A systematic review was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Original studies published between January 1, 2001 and December 31, 2018 and which described the management and/or outcomes of AoD during or after pregnancy in women with MFS were included. Literature searches were conducted. The PubMed search was performed using terms Marfan Syndrome [Mesh] and Pregnancy [Mesh] whereas the Google Scholar search was for “Marfan” and “Pregnancy”, all words anywhere in the article. Results: The literature search yielded 177 articles on PubMed and 13,900 articles on Google Scholar. Assessment of full-text articles for eligibility after removal of duplicates from both databases yielded 12 eligible studies to be included in the final review. Conclusion: Women with MFS are at high risk of aortic dissection during pregnancy and women with aortic root 41-45 mm should consider avoiding pregnancy. Guideline-specific management of aortic aneurysms in pregnancy will reduce the risk of dissection. Diagnosis and Management of MFS need a multidisciplinary approach and team that should start working early in pregnancy. Further studies are needed to optimize medical and surgical approaches in addition to preconception counselling in highrisk subjects." @default.
- W2935862224 created "2019-04-25" @default.
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- W2935862224 date "2020-04-24" @default.
- W2935862224 modified "2023-09-27" @default.
- W2935862224 title "Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review" @default.
- W2935862224 doi "https://doi.org/10.2174/1570161117666190408164612" @default.
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