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- W293587583 abstract "To explore the relationship between the degree of vascular stenosis and cognition in leukoaraiosis patients.A total of 101 leukoaraiosis patients from the Department of Neurology, The First Affiliated Hospital of Anhui Medical University between September 2013 and June 2014, divided into two groups:patients with cognitive impairment (SVCI) (n = 54) , and those without cognitive impairment (NC) (n = 47) . All patients were enrolled and examined by magnetic resonance imaging (MRI) scanning and magnetic resonance angiography (MRA) or computed tomography angiography (CTA). The cognitive assessments were made by MMSE (mini-mental state examination), CAMCOG-C (Cambridge cognitive examination-Chinese version) and CDR (clinical dementia rating). The severity of leukoaraiosis and vascular stenosis was graded by MRI and MRA/CTA scans.The degree of vascular stenosis group and the severity of LA in SVCI were significantly higher than NC (2.0 ± 0.8 vs1.1 ± 0.6, 2.6 ± 1.0 vs 2.0 ± 1.0; P = 0.020, P = 0.003). As white matter level aggravated, cognitive function decreased and vascular stenosis deteriorated accordingly, and the score of MMSE (25 ± 4, 24 ± 6, 22 ± 4) and CAMCOG-C (83 ± 14, 80 ± 14, 73 ± 14) has a statistical significance (P = 0.012, P = 0.014). At the same time, the negative correlation was found in LA patients between cognitive function and severity of LA (r = -0.317, P = 0.001) as well as degree of vascular stenosis (r = -0.284, P = 0.004). Multivariate Logistic regression analysis revealed that, after controlling for various factors, both severity of LA (OR = 2.025, 95% CI 1.307-3.954) and the degree of vascular stenosis (OR = 1.812, 95% CI 1.129-2.908) were risk factors for cognitive impairment in leukoaraiosis patients.Cognition of leukoaraiosis patients is correlated with both severity of leukoaraiosis and vascular stenosis." @default.
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- W293587583 date "2015-01-06" @default.
- W293587583 modified "2023-09-26" @default.
- W293587583 title "[Relationship between vascular stenosis and cognition in leukoaraiosis patients]." @default.
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