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• W2935889764 endingPage "180" @default.
• W2935889764 startingPage "171" @default.
• W2935889764 abstract "Low replicability of animal experiments is perceived as a major hurdle in the field of biomedicine. Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to use isogenic mice. The C57BL/6 strain has evolved as a gold standard strain for this purpose. However, C57BL/6 mice are maintained as substrains by multiple vendors. Evidence exists that the subtle differences between these mouse lines have not been systematically investigated and are often ignored. In the present study, we characterized the female mice of two closely related substrains (C57BL/6J and C57BL/6N) from three vendors in Europe (Charles River Laboratories, Envigo, Janvier Labs) in a battery of behavioral tests. Our data show and confirm substantial behavioral differences between the C57BL/6J and C57BL/6N mice. Importantly, the substrain differences were largely affected by the origin of the animals, as a significant effect of vendor or interaction between the substrain and vendor occurred in all tests. This work highlights the importance of adhering to precise international nomenclature in all publications reporting animal experiments. Moreover, the generalization of research findings from a single mouse substrain can be seriously limited due to genetic drift and environmental variables occurring at different vendors. However, heterogenization of samples, by including animals of different substrains, can enhance generalizability. These issues need to be seriously addressed to improve reproducibility, replicability, and the translational potential of the mouse models. In this study, Åhlgren and Voikar demonstrate that C57BL/6N and C57BL/6J mice from different vendors show substantial behavioral differences, although they are derived from the same strain. These results suggest that different mouse strains and substrains should be included in experiments to address the lack of reproducibility." @default.
• W2935889764 created "2019-04-25" @default.
• W2935889764 creator A5013117593 @default.
• W2935889764 creator A5069677746 @default.
• W2935889764 date "2019-04-22" @default.
• W2935889764 modified "2023-09-25" @default.
• W2935889764 title "Experiments done in Black-6 mice: what does it mean?" @default.
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