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• W2935917039 abstract "Background Lupus nephropathy (LN) is an important cause of morbidity and mortality in patients with Systemic Lupus Erythematosus (SLE). Considering that renal biopsy is a specialized technique and not risk free, a proteomics study is proposed to determine biomarkers that may help us to differentiate patients diagnosed with SLE with and without renal involvement. Methods We selected 12 patients with SLE and renal involvement and 14 patients with SLE without renal involvement. There were no differences between groups according to race, gender and age. The patients were classified as moderate ( Results The Principal Component Analysis (PCA) revealed differences between samples from patients who have high level of proteinuria in 24 hours and patients who do not have renal involvement. Interestingly, patients with mild proteinuria correlated better with patients without renal involvement than with the severe proteinuria group. A total of 292 proteins (identified with at least two peptides with a FDR Interestingly, clear differences were detected between the three subgroups of samples. The Students T-test analysis reflected the differential presence of 147 proteins (p Conclusions A different protein pattern is observed between the groups of patients, so in a more detailed study we may indicate if some of these can serve as prognostic markers for this type of patients. Funding Source(s): No funding" @default.
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• W2935917039 date "2019-04-01" @default.
• W2935917039 modified "2023-10-17" @default.
• W2935917039 title "84 Comparative study in SLE patients with and without renal involvement by label free proteomic analysis of urine" @default.
• W2935917039 doi "https://doi.org/10.1136/lupus-2019-lsm.84" @default.
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