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• W2935960080 abstract "Background: Pulmonary carcinoids are a very rare group of neoplasia. Typical are the most frequent ones, with earlier onset than atypical carcinoids. There is no clear relationship with smoke. Most are indolent and carcinoid syndrome is rare. In the localized disease, surgery is the best choice. In locally advanced disease, radical radiotherapy can be considered. For the metastatic disease, systemic treatment with somatostatin analogs, multi-kinase inhibitors or chemotherapy can be proposed. Methods: We conducted a descriptive and retrospective study including all patients diagnosed with pulmonary carcinoid tumor between January 2013 and January 2018 were included (both localized and metastatic). Other neuroendocrine tumors of the lung were excluded. A Kaplan Meier survival analysis was carried out for each variable to study the overall survival. Results: Of the 42 patients included in the study, most were women (55% vs 45%) and were diagnosed in early stages (83%). Only 14% debuted with metastatic involvement. The main location was the right lung (60%). In 42%, the smoking status is known. Of them, 19% were smokers and 24%, ex-smokers (19% never smoked). 80.5% were diagnosed by cytology (88% as typical and 7.1% as atypical). 12% presented synchronous lung cancer (mostly adenocarcinoma). Localized disease was treated by surgery, mainly by lobectomy (54%). Stage IV patients (66.6%) received systemic treatment with analogs. At the time of the study, 92.7% were still alive (7.3% had died). There were significant differences between tumor stages (p < 0.05) to survival. Even so, there wereńt differences related to age, smoking status or type of surgery. Conclusions: Most of these tumors exhibit a non-aggressive behavior. According to the previous bibliography, the vast majority are diagnosed in early stages. Radical surgery remains as the gold standard. Experienced centers, can use cytology as a diagnostic method, with less morbidity than biopsy. We didńt found a clear association with smoking status, though there was a clear trend towards to the group related to smoke. According to the literature, overall survival of these patients is long and mainly related to the tumor stage (survival at 2 years is > 85%). More studies will be needed to be able to clarify the prognostic impact of factors. Legal entity responsible for the study: Hospital Universitario la Paz - Servicio de Oncología Médica. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest." @default.
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• W2935960080 date "2019-04-01" @default.
• W2935960080 modified "2023-09-26" @default.
• W2935960080 title "Retrospective study about lung carcinoid: Our experience in a Spanish hospital" @default.
• W2935960080 doi "https://doi.org/10.1093/annonc/mdz065.003" @default.
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