FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935979427> ?p ?o ?g. }

• W2935979427 endingPage "e0215464" @default.
• W2935979427 startingPage "e0215464" @default.
• W2935979427 abstract "Introduction Achieving functional cure of chronic HBV infection (Hepatitis B surface antigen [HBsAg] clearance, eventually followed by acquisition of anti-hepatitis B surface antigen [Anti-HBs]) in individuals with HIV and HBV infections is a rare event. In this setting, factors related to HBV cure have not yet been fully characterized. Methods HIV-infected individuals with chronic HBV infection enrolled in the French Dat’AIDS cohort (NCT02898987), who started combined antiretroviral (cART)-anti-HBV treatment were retrospectively analyzed for HBsAg loss and Anti-HBs seroconversion. Results Overall, 1419 naïve-subjects received three different cART-anti-HBV treatment schedule: (1) 3TC or FTC only (n = 150), (2) TDF with or without 3TC or FTC (n = 489) and (3) 3TC or FTC as first line followed by adding/switching to TDF as second line (n = 780). Individuals were followed-up for a median of 89 months (IQR, 56–118). HBV-DNA was < 15 IU/mL in 91% of individuals at the end of the follow-up. Overall, 97 individuals cleared HBsAg (0.7/100 patient-years), of whom, 67 seroconverted for Anti-HBs (0.5/100 patient-years). A high CD4 nadir, a short delay between HBV diagnosis and treatment, a longer time on HBV therapy, an African origin and TDF-based therapy were independent predictors of HBsAg clearance (Probability of odds ratio [OR]>1, >95%) suggested by Bayesian analysis. Also, TDF-based regimen as first line (OR, 3.03) or second line (OR, 2.95) increased rates of HBsAg clearance compared to 3TC or FTC alone, with a 99% probability. Conclusions HBsAg clearance rate was low in HIV-HBV co-infected cART-anti-HBV treated individuals, but was slightly improved on TDF-based regimen." @default.
• W2935979427 created "2019-04-25" @default.
• W2935979427 creator A5003806508 @default.
• W2935979427 creator A5016215468 @default.
• W2935979427 creator A5018167374 @default.
• W2935979427 creator A5042023998 @default.
• W2935979427 creator A5042793861 @default.
• W2935979427 creator A5046960794 @default.
• W2935979427 creator A5047209717 @default.
• W2935979427 creator A5050995200 @default.
• W2935979427 creator A5053097790 @default.
• W2935979427 creator A5054867866 @default.
• W2935979427 creator A5055718888 @default.
• W2935979427 creator A5068872303 @default.
• W2935979427 creator A5086090445 @default.
• W2935979427 creator A5089539215 @default.
• W2935979427 date "2019-04-18" @default.
• W2935979427 modified "2023-10-17" @default.
• W2935979427 title "Higher rates of HBsAg clearance with tenofovir-containing therapy in HBV/HIV co-infection" @default.
• W2935979427 cites W1496455777 @default.
• W2935979427 cites W1723072864 @default.
• W2935979427 cites W1973256067 @default.
• W2935979427 cites W1978364917 @default.
• W2935979427 cites W1988979100 @default.
• W2935979427 cites W1989503541 @default.
• W2935979427 cites W1990405802 @default.
• W2935979427 cites W2025283567 @default.
• W2935979427 cites W2039691068 @default.
• W2935979427 cites W2044734839 @default.
• W2935979427 cites W2047235770 @default.
• W2935979427 cites W2050571266 @default.
• W2935979427 cites W2073237899 @default.
• W2935979427 cites W2119207779 @default.
• W2935979427 cites W2128166983 @default.
• W2935979427 cites W2240377523 @default.
• W2935979427 cites W2291221466 @default.
• W2935979427 cites W2332247812 @default.
• W2935979427 cites W2439379994 @default.
• W2935979427 cites W2531694387 @default.
• W2935979427 cites W2560926253 @default.
• W2935979427 cites W2578332906 @default.
• W2935979427 cites W2600861257 @default.
• W2935979427 cites W2603778119 @default.
• W2935979427 cites W2605785536 @default.
• W2935979427 cites W2606966913 @default.
• W2935979427 cites W2727311941 @default.
• W2935979427 cites W2728120980 @default.
• W2935979427 cites W2746472993 @default.
• W2935979427 cites W2755192742 @default.
• W2935979427 cites W2764064986 @default.
• W2935979427 cites W2781672030 @default.
• W2935979427 cites W2791839818 @default.
• W2935979427 cites W2793017162 @default.
• W2935979427 cites W2796809805 @default.
• W2935979427 cites W2797261428 @default.
• W2935979427 cites W2801812042 @default.
• W2935979427 cites W2803948469 @default.
• W2935979427 doi "https://doi.org/10.1371/journal.pone.0215464" @default.
• W2935979427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6472771" @default.
• W2935979427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30998789" @default.
• W2935979427 hasPublicationYear "2019" @default.
• W2935979427 type Work @default.
• W2935979427 sameAs 2935979427 @default.
• W2935979427 citedByCount "15" @default.
• W2935979427 countsByYear W29359794272020 @default.
• W2935979427 countsByYear W29359794272021 @default.
• W2935979427 countsByYear W29359794272022 @default.
• W2935979427 countsByYear W29359794272023 @default.
• W2935979427 crossrefType "journal-article" @default.
• W2935979427 hasAuthorship W2935979427A5003806508 @default.
• W2935979427 hasAuthorship W2935979427A5016215468 @default.
• W2935979427 hasAuthorship W2935979427A5018167374 @default.
• W2935979427 hasAuthorship W2935979427A5042023998 @default.
• W2935979427 hasAuthorship W2935979427A5042793861 @default.
• W2935979427 hasAuthorship W2935979427A5046960794 @default.
• W2935979427 hasAuthorship W2935979427A5047209717 @default.
• W2935979427 hasAuthorship W2935979427A5050995200 @default.
• W2935979427 hasAuthorship W2935979427A5053097790 @default.
• W2935979427 hasAuthorship W2935979427A5054867866 @default.
• W2935979427 hasAuthorship W2935979427A5055718888 @default.
• W2935979427 hasAuthorship W2935979427A5068872303 @default.
• W2935979427 hasAuthorship W2935979427A5086090445 @default.
• W2935979427 hasAuthorship W2935979427A5089539215 @default.
• W2935979427 hasBestOaLocation W29359794271 @default.
• W2935979427 hasConcept C126322002 @default.
• W2935979427 hasConcept C142462285 @default.
• W2935979427 hasConcept C203014093 @default.
• W2935979427 hasConcept C2522874641 @default.
• W2935979427 hasConcept C2775940106 @default.
• W2935979427 hasConcept C2777382497 @default.
• W2935979427 hasConcept C2777410769 @default.
• W2935979427 hasConcept C2777451964 @default.
• W2935979427 hasConcept C2777869810 @default.
• W2935979427 hasConcept C2780593183 @default.
• W2935979427 hasConcept C2781413609 @default.
• W2935979427 hasConcept C3013748606 @default.
• W2935979427 hasConcept C71924100 @default.
• W2935979427 hasConcept C90924648 @default.

• next