FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2935983171> ?p ?o ?g. }

• W2935983171 endingPage "2343" @default.
• W2935983171 startingPage "2329" @default.
• W2935983171 abstract "Kallikrein-related peptidase 6 (KLK6) is a serine protease normally expressed in mammary tissue and aberrantly regulated in breast cancer. At physiological levels, KLK6 functions as a suppressor of breast cancer, while its aberrant overexpression (> 50-fold higher than normal) is characteristic of a subset of breast cancers and has been linked to accelerated growth of primary breast tumors in severe combined immunodeficiency mice (Pampalakis et al. Cancer Res 2009, 69, 3779). Here, we investigated the molecular mechanisms underlying the concentration-dependent functions of KLK6 by comparing MDA-MB-231 stable transfectants expressing increasing levels of KLK6 in in vitro and in vivo tumorigenicity assays (soft agar, xenograft growth, tail vein metastasis). Quantitative proteomics was applied to identify proteins that are altered upon re-expression of KLK6 in MDA-MB-231 at normal or constitutive levels. Overexpression of KLK6 is associated with increased metastatic ability of breast cancer cells into lungs, increased expression of certain S100 proteins (S100A4, S100A11) and keratins (KRT), and downregulation of the apoptosis-related proteases CASP7 and CASP8, and RABs. On the other hand, KLK6 re-expression at physiological levels leads to inhibition of lung metastases associated with suppression of S100 proteins (S100A4, S100A10, S100A13, S100A16) and induced CASP7 and CASP8 expression. As this is the first report that KLK6 expression is associated with S100 proteins, caspases, RABs, and KRTs, we validated this finding in clinical datasets. By integrating proteomics and microarray data from breast cancer patients, we generated two composite scores, KLK6 + S100B-S100A7 and KLK6 + S100B-S100A14-S100A16, to predict long-term survival of breast cancer patients. We present previously unknown pathways implicating KLK6 in breast cancer. The findings promise to aid our understanding of the functional roles of KLK6 in breast cancer and may yield new biomarkers for the cancer types in which KLK6 is known to be aberrantly upregulated." @default.
• W2935983171 created "2019-04-25" @default.
• W2935983171 creator A5020964577 @default.
• W2935983171 creator A5038476466 @default.
• W2935983171 creator A5039352819 @default.
• W2935983171 creator A5039902738 @default.
• W2935983171 creator A5084226800 @default.
• W2935983171 creator A5087992989 @default.
• W2935983171 creator A5090010013 @default.
• W2935983171 date "2019-09-30" @default.
• W2935983171 modified "2023-10-18" @default.
• W2935983171 title "Biochemical pathways mediated by <scp>KLK</scp> 6 protease in breast cancer" @default.
• W2935983171 cites W1484454235 @default.
• W2935983171 cites W1562387428 @default.
• W2935983171 cites W1969222398 @default.
• W2935983171 cites W1969384522 @default.
• W2935983171 cites W1982149110 @default.
• W2935983171 cites W1992307025 @default.
• W2935983171 cites W1992885568 @default.
• W2935983171 cites W1992909847 @default.
• W2935983171 cites W1996822667 @default.
• W2935983171 cites W1996899827 @default.
• W2935983171 cites W1999384392 @default.
• W2935983171 cites W2003086592 @default.
• W2935983171 cites W2010243889 @default.
• W2935983171 cites W2011247549 @default.
• W2935983171 cites W2014476767 @default.
• W2935983171 cites W2020005240 @default.
• W2935983171 cites W2022380333 @default.
• W2935983171 cites W2028513388 @default.
• W2935983171 cites W2044702943 @default.
• W2935983171 cites W2064495417 @default.
• W2935983171 cites W2066122607 @default.
• W2935983171 cites W2066366129 @default.
• W2935983171 cites W2084296762 @default.
• W2935983171 cites W2084864591 @default.
• W2935983171 cites W2096283457 @default.
• W2935983171 cites W2097255042 @default.
• W2935983171 cites W2099646926 @default.
• W2935983171 cites W2109301975 @default.
• W2935983171 cites W2131730392 @default.
• W2935983171 cites W2131994307 @default.
• W2935983171 cites W2140354759 @default.
• W2935983171 cites W2142739240 @default.
• W2935983171 cites W2143534453 @default.
• W2935983171 cites W2143646930 @default.
• W2935983171 cites W2150144117 @default.
• W2935983171 cites W2150926065 @default.
• W2935983171 cites W2154279182 @default.
• W2935983171 cites W2156177833 @default.
• W2935983171 cites W2169845013 @default.
• W2935983171 cites W2170788312 @default.
• W2935983171 cites W2171364265 @default.
• W2935983171 cites W2194356469 @default.
• W2935983171 cites W2239370303 @default.
• W2935983171 cites W2259802687 @default.
• W2935983171 cites W2316321499 @default.
• W2935983171 cites W2317893384 @default.
• W2935983171 cites W2355239753 @default.
• W2935983171 cites W2383144058 @default.
• W2935983171 cites W2468834741 @default.
• W2935983171 cites W2549204523 @default.
• W2935983171 cites W2560367415 @default.
• W2935983171 cites W2767141291 @default.
• W2935983171 cites W2774285006 @default.
• W2935983171 cites W2788997672 @default.
• W2935983171 cites W2793594125 @default.
• W2935983171 cites W2793829521 @default.
• W2935983171 cites W2795812451 @default.
• W2935983171 cites W2888579500 @default.
• W2935983171 cites W2889646458 @default.
• W2935983171 doi "https://doi.org/10.1002/1878-0261.12493" @default.
• W2935983171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6822253" @default.
• W2935983171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30980596" @default.
• W2935983171 hasPublicationYear "2019" @default.
• W2935983171 type Work @default.
• W2935983171 sameAs 2935983171 @default.
• W2935983171 citedByCount "10" @default.
• W2935983171 countsByYear W29359831712020 @default.
• W2935983171 countsByYear W29359831712021 @default.
• W2935983171 countsByYear W29359831712022 @default.
• W2935983171 countsByYear W29359831712023 @default.
• W2935983171 crossrefType "journal-article" @default.
• W2935983171 hasAuthorship W2935983171A5020964577 @default.
• W2935983171 hasAuthorship W2935983171A5038476466 @default.
• W2935983171 hasAuthorship W2935983171A5039352819 @default.
• W2935983171 hasAuthorship W2935983171A5039902738 @default.
• W2935983171 hasAuthorship W2935983171A5084226800 @default.
• W2935983171 hasAuthorship W2935983171A5087992989 @default.
• W2935983171 hasAuthorship W2935983171A5090010013 @default.
• W2935983171 hasBestOaLocation W29359831711 @default.
• W2935983171 hasConcept C104317684 @default.
• W2935983171 hasConcept C121608353 @default.
• W2935983171 hasConcept C127561419 @default.
• W2935983171 hasConcept C153911025 @default.
• W2935983171 hasConcept C190283241 @default.
• W2935983171 hasConcept C46111723 @default.
• W2935983171 hasConcept C502942594 @default.

• next