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- W2936000882 abstract "AbstractThe hypothesis connecting dyshomeostasis of selected metal ions in the brain with increased probability of the development of severe neurodegenerative diseases is gaining increasing attention. The mechanisms of metal toxicity can be studied using different methodologies. One of the approaches is based on peptides as mimetics of the metal binding sites in proteins. In our studies, we have focused on human cystatin C (hCC) as one of the proteins involved in neurodegeneration. Physiologically, it is an important inhibitor of cysteine proteases and modulator of many physiological and pathological states. Native hCC is present at particularly high concentrations in cerebrospinal fluid (CSF) and was shown to possess both neurodegenerative and neuroprotective propensities. We have studied the copper(II) binding to its C-terminal fragment containing two histidine residues as potential site(s) for metal coordination. Our data indicate that the hCC fragment is fully capable of effective metal binding. Moreo..." @default.
- W2936000882 created "2019-04-25" @default.
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- W2936000882 date "2019-04-20" @default.
- W2936000882 modified "2023-10-03" @default.
- W2936000882 title "First studies on the interactions of the C-terminal cystatin C fragment 85–94 with Cu(II) ions" @default.
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- W2936000882 doi "https://doi.org/10.1080/00958972.2019.1605065" @default.
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