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- W2936044468 abstract "Lupus erythematosus (LE) is an autoimmune disease with a broad clinical spectrum ranging from cutaneous lesions to severe systemic manifestations. Clinically, lupus patients with skin lesions can be divided into two subsets based on the organs involved: cutaneous LE (CLE), such as discoid LE (DLE), and systemic LE (SLE), e.g., acute LE (ACLE). Interestingly, the excessive production of autoantibodies can be found in serum and skin lesions of SLE, however, increased autoantibodies appear in skin lesions rather than serum of DLE. By now the pathomechanism of immune deposition in DLE remains unclear. Herein, with Multiplex immunofluorescence microscopy, in over half of 112 DLE biopsies, lymphoid aggregates ranged from tight clusters of B cells and T cells to highly organized structures that comprise functional germinal centres (GCs) (In 58% of cases (66/112), there were well-circumscribed aggregates of CD19+ B cells with CD4+ T cells. In 8% of biopsies (10/112), structures similar to GCs of human tonsil were observed.). Moreover, compared with SLE, the percentage of T cells in DLE showed no statistical difference (n=20, P=0.158), but the percentage of B cells was significantly higher in DLE (n = 20, P=0.0022). 5 samples were selected respectively from two group of LE to detect the proportions of Tfh cells (CD4/IL21/BCL6/PD-1/CXCR5). Then we found a significantly increased population of T follicular helper (Tfh)-like cells expressing IL21, PD-1 and Bcl-6 but lacking CXCR5 in the dermis of DLE as compared to the SLE (n=5, P=0.0060). Meanwhile, we found an increased IL-21 in the lesion of DLE, as well as in non-Tfh-like cells , which is upstream of Bcl-6. Abnormal increased IL-21 and Tfh-like cells in dermis may contribute to the formation of ectopic GCs structures and immune deposition in DLE. Our findings might provide new mechanisms for pathogenesis of DLE, as well as providing potential therapeutic targets." @default.
- W2936044468 created "2019-04-25" @default.
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- W2936044468 date "2019-05-01" @default.
- W2936044468 modified "2023-09-29" @default.
- W2936044468 title "083 Increased T follicular helper-like cells and tertiary lymphoid structures in the skin lesions of discoid lupus erythematosus" @default.
- W2936044468 doi "https://doi.org/10.1016/j.jid.2019.03.159" @default.
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