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- W2936047476 abstract "Pten mutations are associated with autism spectrum disorder. Pten loss of function in neurons increases excitatory synaptic connectivity, contributing to an imbalance between excitation and inhibition. We aimed to determine whether Pten loss results in aberrant connectivity in neural circuits. We compared postnatally generated wild-type and Pten knockout granule neurons integrating into the dentate gyrus using a variety of methods to examine their connectivity. We found that postsynaptic Pten loss provides an advantage to dendritic spines in competition over a limited pool of presynaptic boutons. Retrograde monosynaptic tracing with rabies virus reveals that this results in synaptic contact with more presynaptic partners. Using independently excitable opsins to interrogate multiple inputs onto a single neuron, we found that excess connectivity is established indiscriminately from among glutamatergic afferents. Therefore, Pten loss results in inappropriate connectivity whereby neurons are coupled to a greater number of synaptic partners." @default.
- W2936047476 created "2019-04-25" @default.
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- W2936047476 date "2019-04-09" @default.
- W2936047476 modified "2023-10-17" @default.
- W2936047476 title "Pten loss results in inappropriate excitatory connectivity" @default.
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- W2936047476 doi "https://doi.org/10.1038/s41380-019-0412-6" @default.
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