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- W2936057910 abstract "Flavor is the combination of gustatory, olfactory and trigeminal sensations, representing the three main sensory pathways that allow detecting environmental chemical substances. Taste, in particular, is a complex chemosensory path that allows identification of substances present in ingested foods and beverages. In this manuscript, we propose a conceptual roadmap from aspects related to the evolution and the physiological role of taste, up to the current knowledge about its implication in the modulation of a healthy state, or obesity. More specifically, we focused on the role of stimulation of taste receptors in releasing gut hormones (also known as enterohormones), and their effects on the regulation of food intake, by inducing satiety, either by locally acting (in the gastrointestinal tract), or centrally (in the brain). Recent evidence demonstrated that some enterohormones are able to modulate gastrointestinal motility, thus affecting an orexigenic responses in the central nervous system. In keeping with this, we discuss the ability of the gustatory system to be a final checkpoint control for food intake regulation, and we speculate about taste perception manipulation in the management of obesity." @default.
- W2936057910 created "2019-04-25" @default.
- W2936057910 creator A5014566953 @default.
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- W2936057910 date "2019-04-01" @default.
- W2936057910 modified "2023-09-24" @default.
- W2936057910 title "Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity" @default.
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- W2936057910 doi "https://doi.org/10.1038/s41367-019-0012-6" @default.
- W2936057910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6683113" @default.
- W2936057910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31391920" @default.