FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936065541> ?p ?o ?g. }

• W2936065541 endingPage "19552" @default.
• W2936065541 startingPage "19539" @default.
• W2936065541 abstract "Didscoidin domain receptor 1 (DDR1) is involved in the progression of prostate cancer metastasis through stimulation of epithelial-mesenchymal transition (EMT). So DDR1 inhibition can be a helpful target for cancer metastasis prevention. So, we studied the effects of DDR1 inhibition on EMT as well as induction of cell-cycle arrest and apoptosis in prostate cancer cell lines. DDR1 expression was evaluated using reverse-transcription polymerase chain reaction and western blot analysis. The EMT-associated protein expression was determined using the western blot analysis and immunocytochemistry following treatment with various concentrations of DDR1 inhibitor. The activation of DDR1 and also downstream-signaling molecules Pyk2 and MKK7 were determined using western blot analysis. Cell survival and proliferation after DDR1 inhibition were evaluated using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide, bromodeoxyuridine, and colony formation assays. Flow cytometry analysis was used to determine the effects of DDR1 inhibition on cell-cycle arrest and apoptosis using annexin V/propidium iodide-based flow cytometry. Results showed that the protein expression of N-cadherin and vimentin were decreased whereas protein expression of E-cadherin was increased after DDR1 inhibition. Results of our western blot analysis indicated that DDR1 inhibitor effectively downregulated P-DDR1, P-Pyk2, and P-MKK7 levels. This result also showed that DDR1 inhibition decreased cell survival and proliferation, induced G1 cell-cycle arrest, induced apoptosis by an increase in the Bax/Bcl-2 ratio and depletion of the mitochondrial membrane potential, and also by reactive oxygen species creation in prostate cancer cells. These data show that DDR1 inhibition can result in the EMT prevention via inhibition of Pyk2 and MKK7 signaling pathway and induces cell-cycle arrest and apoptosis in prostate cancer cell lines. Thus, this study identifies DDR1 as an important target for modulating EMT and induction of apoptosis in prostate cancer cells." @default.
• W2936065541 created "2019-04-25" @default.
• W2936065541 creator A5050281991 @default.
• W2936065541 creator A5060858141 @default.
• W2936065541 creator A5071032032 @default.
• W2936065541 creator A5073774327 @default.
• W2936065541 date "2019-04-08" @default.
• W2936065541 modified "2023-10-02" @default.
• W2936065541 title "Inhibition of didscoidin domain receptor 1 reduces epithelial–mesenchymal transition and induce cell‐cycle arrest and apoptosis in prostate cancer cell lines" @default.
• W2936065541 cites W1845652870 @default.
• W2936065541 cites W1981197649 @default.
• W2936065541 cites W1984192137 @default.
• W2936065541 cites W2007023713 @default.
• W2936065541 cites W2032930150 @default.
• W2936065541 cites W2059253566 @default.
• W2936065541 cites W2082905439 @default.
• W2936065541 cites W2101083650 @default.
• W2936065541 cites W2121000910 @default.
• W2936065541 cites W2145968308 @default.
• W2936065541 cites W2154197027 @default.
• W2936065541 cites W2235523093 @default.
• W2936065541 cites W2334648051 @default.
• W2936065541 cites W2515281308 @default.
• W2936065541 cites W2515845266 @default.
• W2936065541 cites W2752807922 @default.
• W2936065541 cites W2770064340 @default.
• W2936065541 cites W2787849300 @default.
• W2936065541 cites W2800357893 @default.
• W2936065541 cites W2886206782 @default.
• W2936065541 cites W2892175032 @default.
• W2936065541 doi "https://doi.org/10.1002/jcp.28552" @default.
• W2936065541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30963567" @default.
• W2936065541 hasPublicationYear "2019" @default.
• W2936065541 type Work @default.
• W2936065541 sameAs 2936065541 @default.
• W2936065541 citedByCount "27" @default.
• W2936065541 countsByYear W29360655412019 @default.
• W2936065541 countsByYear W29360655412020 @default.
• W2936065541 countsByYear W29360655412021 @default.
• W2936065541 countsByYear W29360655412022 @default.
• W2936065541 countsByYear W29360655412023 @default.
• W2936065541 crossrefType "journal-article" @default.
• W2936065541 hasAuthorship W2936065541A5050281991 @default.
• W2936065541 hasAuthorship W2936065541A5060858141 @default.
• W2936065541 hasAuthorship W2936065541A5071032032 @default.
• W2936065541 hasAuthorship W2936065541A5073774327 @default.
• W2936065541 hasConcept C101544691 @default.
• W2936065541 hasConcept C104317684 @default.
• W2936065541 hasConcept C121608353 @default.
• W2936065541 hasConcept C147447768 @default.
• W2936065541 hasConcept C152681006 @default.
• W2936065541 hasConcept C153911025 @default.
• W2936065541 hasConcept C185592680 @default.
• W2936065541 hasConcept C190283241 @default.
• W2936065541 hasConcept C203014093 @default.
• W2936065541 hasConcept C204232928 @default.
• W2936065541 hasConcept C2775934118 @default.
• W2936065541 hasConcept C2776415932 @default.
• W2936065541 hasConcept C2779013556 @default.
• W2936065541 hasConcept C29537977 @default.
• W2936065541 hasConcept C31573885 @default.
• W2936065541 hasConcept C502942594 @default.
• W2936065541 hasConcept C54355233 @default.
• W2936065541 hasConcept C553184892 @default.
• W2936065541 hasConcept C55493867 @default.
• W2936065541 hasConcept C62112901 @default.
• W2936065541 hasConcept C62478195 @default.
• W2936065541 hasConcept C76419328 @default.
• W2936065541 hasConcept C86803240 @default.
• W2936065541 hasConcept C88634738 @default.
• W2936065541 hasConcept C95444343 @default.
• W2936065541 hasConceptScore W2936065541C101544691 @default.
• W2936065541 hasConceptScore W2936065541C104317684 @default.
• W2936065541 hasConceptScore W2936065541C121608353 @default.
• W2936065541 hasConceptScore W2936065541C147447768 @default.
• W2936065541 hasConceptScore W2936065541C152681006 @default.
• W2936065541 hasConceptScore W2936065541C153911025 @default.
• W2936065541 hasConceptScore W2936065541C185592680 @default.
• W2936065541 hasConceptScore W2936065541C190283241 @default.
• W2936065541 hasConceptScore W2936065541C203014093 @default.
• W2936065541 hasConceptScore W2936065541C204232928 @default.
• W2936065541 hasConceptScore W2936065541C2775934118 @default.
• W2936065541 hasConceptScore W2936065541C2776415932 @default.
• W2936065541 hasConceptScore W2936065541C2779013556 @default.
• W2936065541 hasConceptScore W2936065541C29537977 @default.
• W2936065541 hasConceptScore W2936065541C31573885 @default.
• W2936065541 hasConceptScore W2936065541C502942594 @default.
• W2936065541 hasConceptScore W2936065541C54355233 @default.
• W2936065541 hasConceptScore W2936065541C553184892 @default.
• W2936065541 hasConceptScore W2936065541C55493867 @default.
• W2936065541 hasConceptScore W2936065541C62112901 @default.
• W2936065541 hasConceptScore W2936065541C62478195 @default.
• W2936065541 hasConceptScore W2936065541C76419328 @default.
• W2936065541 hasConceptScore W2936065541C86803240 @default.
• W2936065541 hasConceptScore W2936065541C88634738 @default.
• W2936065541 hasConceptScore W2936065541C95444343 @default.
• W2936065541 hasFunder F4320322245 @default.
• W2936065541 hasIssue "11" @default.

• next