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• W2936112401 abstract "Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: “conservative” and “disruptive.” Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman’s correlation between edgewise baseline FC (at 14 y, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML overflow=scroll> <mml:mi>F</mml:mi> <mml:msub> <mml:mrow> <mml:mi>C</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>14</mml:mn> </mml:mrow> </mml:msub> </mml:math> ) and adolescent change in FC ( <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML overflow=scroll> <mml:mi mathvariant=normal>Δ</mml:mi> <mml:mi>F</mml:mi> <mml:msub> <mml:mrow> <mml:mi>C</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>14</mml:mn> <mml:mo>−</mml:mo> <mml:mn>26</mml:mn> </mml:mrow> </mml:msub> </mml:math> ), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas." @default.
• W2936112401 created "2019-04-25" @default.
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• W2936112401 date "2020-01-28" @default.
• W2936112401 modified "2023-10-11" @default.
• W2936112401 title "Conservative and disruptive modes of adolescent change in human brain functional connectivity" @default.
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• W2936112401 doi "https://doi.org/10.1073/pnas.1906144117" @default.
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