Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936183454> ?p ?o ?g. }
- W2936183454 endingPage "831" @default.
- W2936183454 startingPage "812" @default.
- W2936183454 abstract "Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL-6 family of cytokines now consists of ten members. Although some of the family members’ functions are redundant as a result of the expression of gp130, there are also functional distinctions between members. The mechanisms that determine functional redundancies and distinctions are not completely understood. Yet, research has clarified the role of IL-6 family cytokines in autoimmune diseases and has led to effective therapies that target them. Here, we review the IL-6 family of cytokines in autoimmune diseases, with a particular focus on the prototypical member IL-6, from the viewpoints of their structure, signaling, and biological features and discuss possible mechanisms of their functional pleiotropy. Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL-6 family of cytokines now consists of ten members. Although some of the family members’ functions are redundant as a result of the expression of gp130, there are also functional distinctions between members. The mechanisms that determine functional redundancies and distinctions are not completely understood. Yet, research has clarified the role of IL-6 family cytokines in autoimmune diseases and has led to effective therapies that target them. Here, we review the IL-6 family of cytokines in autoimmune diseases, with a particular focus on the prototypical member IL-6, from the viewpoints of their structure, signaling, and biological features and discuss possible mechanisms of their functional pleiotropy." @default.
- W2936183454 created "2019-04-25" @default.
- W2936183454 creator A5056051274 @default.
- W2936183454 creator A5063407770 @default.
- W2936183454 creator A5068093589 @default.
- W2936183454 date "2019-04-01" @default.
- W2936183454 modified "2023-10-16" @default.
- W2936183454 title "Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines" @default.
- W2936183454 cites W1163304163 @default.
- W2936183454 cites W1462845024 @default.
- W2936183454 cites W1479791469 @default.
- W2936183454 cites W1485562629 @default.
- W2936183454 cites W1496109170 @default.
- W2936183454 cites W1502312172 @default.
- W2936183454 cites W1507469709 @default.
- W2936183454 cites W1516719898 @default.
- W2936183454 cites W1520921451 @default.
- W2936183454 cites W1537488315 @default.
- W2936183454 cites W1539584528 @default.
- W2936183454 cites W1540487906 @default.
- W2936183454 cites W1541529837 @default.
- W2936183454 cites W155372178 @default.
- W2936183454 cites W1569271652 @default.
- W2936183454 cites W1583308104 @default.
- W2936183454 cites W1597588755 @default.
- W2936183454 cites W1603285606 @default.
- W2936183454 cites W1653876320 @default.
- W2936183454 cites W1718175705 @default.
- W2936183454 cites W1747209029 @default.
- W2936183454 cites W1806775765 @default.
- W2936183454 cites W1810441673 @default.
- W2936183454 cites W1824670638 @default.
- W2936183454 cites W1836377684 @default.
- W2936183454 cites W1838662971 @default.
- W2936183454 cites W1847326477 @default.
- W2936183454 cites W1854638296 @default.
- W2936183454 cites W1903535291 @default.
- W2936183454 cites W1903887594 @default.
- W2936183454 cites W1914550558 @default.
- W2936183454 cites W1945946018 @default.
- W2936183454 cites W1955814101 @default.
- W2936183454 cites W1966922635 @default.
- W2936183454 cites W1968814677 @default.
- W2936183454 cites W1971908211 @default.
- W2936183454 cites W1972343772 @default.
- W2936183454 cites W1972932855 @default.
- W2936183454 cites W1974267497 @default.
- W2936183454 cites W1975773833 @default.
- W2936183454 cites W1976067168 @default.
- W2936183454 cites W1976302032 @default.
- W2936183454 cites W1976707950 @default.
- W2936183454 cites W1980924577 @default.
- W2936183454 cites W1981892481 @default.
- W2936183454 cites W1981969796 @default.
- W2936183454 cites W1982931411 @default.
- W2936183454 cites W1983191343 @default.
- W2936183454 cites W1983224547 @default.
- W2936183454 cites W1984467626 @default.
- W2936183454 cites W1984763799 @default.
- W2936183454 cites W1986543207 @default.
- W2936183454 cites W1987408673 @default.
- W2936183454 cites W1988885940 @default.
- W2936183454 cites W1988917700 @default.
- W2936183454 cites W1989588757 @default.
- W2936183454 cites W1989590412 @default.
- W2936183454 cites W1990825882 @default.
- W2936183454 cites W1991055608 @default.
- W2936183454 cites W1991687240 @default.
- W2936183454 cites W1993739493 @default.
- W2936183454 cites W1995559307 @default.
- W2936183454 cites W1996131506 @default.
- W2936183454 cites W1996548067 @default.
- W2936183454 cites W1998009350 @default.
- W2936183454 cites W1999821753 @default.
- W2936183454 cites W2000689693 @default.
- W2936183454 cites W2001668845 @default.
- W2936183454 cites W2001941062 @default.
- W2936183454 cites W2002076761 @default.
- W2936183454 cites W2003363988 @default.
- W2936183454 cites W2003505321 @default.
- W2936183454 cites W2004907641 @default.
- W2936183454 cites W2005182655 @default.
- W2936183454 cites W2005529661 @default.
- W2936183454 cites W2007000374 @default.
- W2936183454 cites W2007268662 @default.
- W2936183454 cites W2007716988 @default.
- W2936183454 cites W2012123837 @default.
- W2936183454 cites W2012379047 @default.
- W2936183454 cites W2013167680 @default.
- W2936183454 cites W2013196445 @default.
- W2936183454 cites W2013363382 @default.
- W2936183454 cites W2014660851 @default.
- W2936183454 cites W2016956768 @default.
- W2936183454 cites W2017223857 @default.
- W2936183454 cites W2019466258 @default.
- W2936183454 cites W2019663885 @default.
- W2936183454 cites W2020222990 @default.
- W2936183454 cites W2022123949 @default.