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• W2936193003 abstract "Self-renewal and pluripotency of the embryonic stem cell (ESC) state are established and maintained by multiple regulatory networks that comprise transcription factors and epigenetic regulators. While much has been learned regarding transcription factors, the function of epigenetic regulators in these networks is less well defined. We conducted a CRISPR-Cas9-mediated loss-of-function genetic screen that identified two epigenetic regulators, TAF5L and TAF6L, components or co-activators of the GNAT-HAT complexes for the mouse ESC (mESC) state. Detailed molecular studies demonstrate that TAF5L/TAF6L transcriptionally activate c-Myc and Oct4 and their corresponding MYC and CORE regulatory networks. Besides, TAF5L/TAF6L predominantly regulate their target genes through H3K9ac deposition and c-MYC recruitment that eventually activate the MYC regulatory network for self-renewal of mESCs. Thus, our findings uncover a role of TAF5L/TAF6L in directing the MYC regulatory network that orchestrates gene expression programs to control self-renewal for the maintenance of mESC state." @default.
• W2936193003 created "2019-04-25" @default.
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• W2936193003 date "2019-06-01" @default.
• W2936193003 modified "2023-10-10" @default.
• W2936193003 title "TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network" @default.
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• W2936193003 doi "https://doi.org/10.1016/j.molcel.2019.03.025" @default.
• W2936193003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6671628" @default.
• W2936193003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31005419" @default.
• W2936193003 hasPublicationYear "2019" @default.
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