Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936223015> ?p ?o ?g. }
- W2936223015 abstract "Drugs have multiple, not single, effects. Decomposition of drug effects into basic components helps us to understand the pharmacological properties of a drug and contributes to drug discovery. We have extended factor analysis and developed a novel profile data analysis method: orthogonal linear separation analysis (OLSA). OLSA contracted 11,911 genes to 118 factors from transcriptome data of MCF7 cells treated with 318 compounds in a Connectivity Map. Ontology of the main genes constituting the factors detected significant enrichment of the ontology in 65 of 118 factors and similar results were obtained in two other data sets. In further analysis of the Connectivity Map data set, one factor discriminated two Hsp90 inhibitors, geldanamycin and radicicol, while clustering analysis could not. Doxorubicin and other topoisomerase inhibitors were estimated to inhibit Na+/K+ ATPase, one of the suggested mechanisms of doxorubicin-induced cardiotoxicity. Based on the factor including PI3K/AKT/mTORC1 inhibition activity, 5 compounds were predicted to be novel inducers of autophagy, and other analyses including western blotting revealed that 4 of the 5 actually induced autophagy. These findings indicate the potential of OLSA to decompose the effects of a drug and identify its basic components." @default.
- W2936223015 created "2019-04-25" @default.
- W2936223015 creator A5002472002 @default.
- W2936223015 creator A5032877897 @default.
- W2936223015 creator A5061014418 @default.
- W2936223015 creator A5078120307 @default.
- W2936223015 creator A5083177822 @default.
- W2936223015 date "2019-02-12" @default.
- W2936223015 modified "2023-10-16" @default.
- W2936223015 title "Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components" @default.
- W2936223015 cites W1480855513 @default.
- W2936223015 cites W1519997692 @default.
- W2936223015 cites W1559059998 @default.
- W2936223015 cites W1804602290 @default.
- W2936223015 cites W1971732845 @default.
- W2936223015 cites W1987566410 @default.
- W2936223015 cites W1991054314 @default.
- W2936223015 cites W1994440886 @default.
- W2936223015 cites W2009329529 @default.
- W2936223015 cites W2040990879 @default.
- W2936223015 cites W2041503985 @default.
- W2936223015 cites W2046333488 @default.
- W2936223015 cites W2052082934 @default.
- W2936223015 cites W2052297334 @default.
- W2936223015 cites W2067487872 @default.
- W2936223015 cites W2068509606 @default.
- W2936223015 cites W2072249094 @default.
- W2936223015 cites W2091999953 @default.
- W2936223015 cites W2099582158 @default.
- W2936223015 cites W2103017472 @default.
- W2936223015 cites W2104381422 @default.
- W2936223015 cites W2106592879 @default.
- W2936223015 cites W2112265988 @default.
- W2936223015 cites W2121604817 @default.
- W2936223015 cites W2122189144 @default.
- W2936223015 cites W2123106337 @default.
- W2936223015 cites W2130498948 @default.
- W2936223015 cites W2131725992 @default.
- W2936223015 cites W2138814935 @default.
- W2936223015 cites W2142610855 @default.
- W2936223015 cites W2154731450 @default.
- W2936223015 cites W2155299850 @default.
- W2936223015 cites W2159940675 @default.
- W2936223015 cites W2164778558 @default.
- W2936223015 cites W2170802476 @default.
- W2936223015 cites W2193667665 @default.
- W2936223015 cites W2224812643 @default.
- W2936223015 cites W2398183597 @default.
- W2936223015 cites W2520354325 @default.
- W2936223015 cites W2547933649 @default.
- W2936223015 cites W2581042027 @default.
- W2936223015 cites W2612467560 @default.
- W2936223015 cites W2621725158 @default.
- W2936223015 cites W2725171488 @default.
- W2936223015 cites W2766600422 @default.
- W2936223015 cites W2784709079 @default.
- W2936223015 cites W2789422103 @default.
- W2936223015 cites W2792686433 @default.
- W2936223015 cites W2793742848 @default.
- W2936223015 cites W2796168841 @default.
- W2936223015 cites W2800221771 @default.
- W2936223015 cites W2802494300 @default.
- W2936223015 cites W2804801760 @default.
- W2936223015 cites W2807209585 @default.
- W2936223015 cites W2808845633 @default.
- W2936223015 cites W2951333071 @default.
- W2936223015 cites W3098921839 @default.
- W2936223015 doi "https://doi.org/10.1038/s41598-019-38528-4" @default.
- W2936223015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6372619" @default.
- W2936223015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755704" @default.
- W2936223015 hasPublicationYear "2019" @default.
- W2936223015 type Work @default.
- W2936223015 sameAs 2936223015 @default.
- W2936223015 citedByCount "9" @default.
- W2936223015 countsByYear W29362230152019 @default.
- W2936223015 countsByYear W29362230152020 @default.
- W2936223015 countsByYear W29362230152022 @default.
- W2936223015 countsByYear W29362230152023 @default.
- W2936223015 crossrefType "journal-article" @default.
- W2936223015 hasAuthorship W2936223015A5002472002 @default.
- W2936223015 hasAuthorship W2936223015A5032877897 @default.
- W2936223015 hasAuthorship W2936223015A5061014418 @default.
- W2936223015 hasAuthorship W2936223015A5078120307 @default.
- W2936223015 hasAuthorship W2936223015A5083177822 @default.
- W2936223015 hasBestOaLocation W29362230151 @default.
- W2936223015 hasConcept C2780035454 @default.
- W2936223015 hasConcept C60644358 @default.
- W2936223015 hasConcept C70721500 @default.
- W2936223015 hasConcept C86803240 @default.
- W2936223015 hasConcept C98274493 @default.
- W2936223015 hasConceptScore W2936223015C2780035454 @default.
- W2936223015 hasConceptScore W2936223015C60644358 @default.
- W2936223015 hasConceptScore W2936223015C70721500 @default.
- W2936223015 hasConceptScore W2936223015C86803240 @default.
- W2936223015 hasConceptScore W2936223015C98274493 @default.
- W2936223015 hasIssue "1" @default.
- W2936223015 hasLocation W29362230151 @default.
- W2936223015 hasLocation W29362230152 @default.
- W2936223015 hasLocation W29362230153 @default.
- W2936223015 hasLocation W29362230154 @default.