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- W2936242743 abstract "Functional dyspepsia (FD) is a common chronic gastrointestinal disorder with a complex, undefined mechanism. Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility. PubMed, EMBASE, the Cochrane Library, and HuGE database were searched. An additive model was adopted to determine whether previous studied genes are associated with FD susceptibility. Carriers of minor allele in GNB3 825C>T (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.15</mml:mn></mml:math>, 95% CI 0.99-1.34, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.07</mml:mn></mml:math>), SCL6A4 5HTTLPR (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>0.92</mml:mn></mml:math>, 95% CI 0.75-1.12, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.40</mml:mn></mml:math>), and CCK-1R 779T>C (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>0.86</mml:mn></mml:math>, 95% CI 0.72-1.03, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.09</mml:mn></mml:math>) genes failed to demonstrate susceptibility to FD. In a subgroup analysis, only minor allele (T) in GNB3 825C>T was associated with an increased susceptibility to the epigastric pain syndrome subtype (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.34</mml:mn></mml:math>, 95% CI 1.10-1.63, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.003</mml:mn></mml:math>). Our meta-analysis based on available studies using an additive model failed to show that GNB3, SCL6A4, and CCK-1R polymorphisms are associated with FD susceptibility." @default.
- W2936242743 created "2019-04-25" @default.
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- W2936242743 date "2019-04-15" @default.
- W2936242743 modified "2023-10-17" @default.
- W2936242743 title "Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis" @default.
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- W2936242743 doi "https://doi.org/10.1155/2019/3420548" @default.
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