FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936315805> ?p ?o ?g. }

• W2936315805 endingPage "2144" @default.
• W2936315805 startingPage "2133" @default.
• W2936315805 abstract "Diabetic individuals are at considerable risk for invasive infection by Staphylococcus aureus, however, the mechanisms underlying this enhanced susceptibility to infection are unclear. We observed increased mortality following i.v. S. aureus infection in diabetic mice compared with nondiabetic controls, correlating with increased numbers of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs). LDNs have been implicated in the inflammatory pathology of diseases such as lupus, given their release of large amounts of NETs. Our goal was to describe what drives LDN increases during S. aureus infection in the diabetic host and mechanisms that promote increased NET production by LDNs. LDN development is dependent on TGF-β, which we found to be more activated in the diabetic host. Neutralization of TGF-β, or the TGF-β-activating integrin αvβ8, reduced LDN numbers and improved survival during S. aureus infection. Targeting S. aureus directly with MEDI4893*, an α toxin-neutralizing monoclonal antibody, blocked TGF-β activation, reduced LDNs and NETs, and significantly improved survival. A comparison of gene and protein expression in high-density neutrophils and LDNs identified increased GPCRs and elevated phosphatase and tensin homolog (PTEN) in the LDN subset. Inhibition of PTEN improved the survival of infected diabetic mice. Our data identify a population of neutrophils in infected diabetic mice that correlated with decreased survival and increased NET production and describe 3 therapeutic targets, a bacterial target and 2 host proteins, that prevented NET production and improved survival." @default.
• W2936315805 created "2019-04-25" @default.
• W2936315805 creator A5018340663 @default.
• W2936315805 creator A5019050839 @default.
• W2936315805 creator A5034101434 @default.
• W2936315805 creator A5035130163 @default.
• W2936315805 creator A5039181422 @default.
• W2936315805 creator A5042853158 @default.
• W2936315805 creator A5045318953 @default.
• W2936315805 creator A5046158954 @default.
• W2936315805 creator A5050859911 @default.
• W2936315805 creator A5054278526 @default.
• W2936315805 creator A5059285590 @default.
• W2936315805 creator A5062517466 @default.
• W2936315805 creator A5067042263 @default.
• W2936315805 creator A5075072986 @default.
• W2936315805 date "2019-04-15" @default.
• W2936315805 modified "2023-10-09" @default.
• W2936315805 title "Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice" @default.
• W2936315805 cites W1506816482 @default.
• W2936315805 cites W1531026153 @default.
• W2936315805 cites W1584463243 @default.
• W2936315805 cites W1663371441 @default.
• W2936315805 cites W1913879859 @default.
• W2936315805 cites W1992232557 @default.
• W2936315805 cites W2002157461 @default.
• W2936315805 cites W2011196153 @default.
• W2936315805 cites W2014466662 @default.
• W2936315805 cites W2023280240 @default.
• W2936315805 cites W2040916923 @default.
• W2936315805 cites W2048801137 @default.
• W2936315805 cites W2052328579 @default.
• W2936315805 cites W2054451338 @default.
• W2936315805 cites W2060253107 @default.
• W2936315805 cites W2066714887 @default.
• W2936315805 cites W2074331191 @default.
• W2936315805 cites W2076271925 @default.
• W2936315805 cites W2091545748 @default.
• W2936315805 cites W2099356583 @default.
• W2936315805 cites W2112313575 @default.
• W2936315805 cites W2118217258 @default.
• W2936315805 cites W2120138780 @default.
• W2936315805 cites W2124522940 @default.
• W2936315805 cites W2124902151 @default.
• W2936315805 cites W2126643946 @default.
• W2936315805 cites W2134625111 @default.
• W2936315805 cites W2147511225 @default.
• W2936315805 cites W2190960426 @default.
• W2936315805 cites W2254774777 @default.
• W2936315805 cites W2261479737 @default.
• W2936315805 cites W2295606463 @default.
• W2936315805 cites W2296386957 @default.
• W2936315805 cites W2331625487 @default.
• W2936315805 cites W2342532453 @default.
• W2936315805 cites W2541536818 @default.
• W2936315805 cites W2566985280 @default.
• W2936315805 cites W2593144838 @default.
• W2936315805 cites W2612492001 @default.
• W2936315805 cites W2617454206 @default.
• W2936315805 cites W2748227714 @default.
• W2936315805 cites W2758829149 @default.
• W2936315805 cites W2762762130 @default.
• W2936315805 cites W2790463575 @default.
• W2936315805 cites W2802559055 @default.
• W2936315805 cites W2803139640 @default.
• W2936315805 cites W2810427028 @default.
• W2936315805 cites W2884110883 @default.
• W2936315805 cites W2894451493 @default.
• W2936315805 cites W2897882351 @default.
• W2936315805 cites W4211252508 @default.
• W2936315805 doi "https://doi.org/10.1172/jci126938" @default.
• W2936315805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486344" @default.
• W2936315805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30985291" @default.
• W2936315805 hasPublicationYear "2019" @default.
• W2936315805 type Work @default.
• W2936315805 sameAs 2936315805 @default.
• W2936315805 citedByCount "29" @default.
• W2936315805 countsByYear W29363158052020 @default.
• W2936315805 countsByYear W29363158052021 @default.
• W2936315805 countsByYear W29363158052022 @default.
• W2936315805 countsByYear W29363158052023 @default.
• W2936315805 crossrefType "journal-article" @default.
• W2936315805 hasAuthorship W2936315805A5018340663 @default.
• W2936315805 hasAuthorship W2936315805A5019050839 @default.
• W2936315805 hasAuthorship W2936315805A5034101434 @default.
• W2936315805 hasAuthorship W2936315805A5035130163 @default.
• W2936315805 hasAuthorship W2936315805A5039181422 @default.
• W2936315805 hasAuthorship W2936315805A5042853158 @default.
• W2936315805 hasAuthorship W2936315805A5045318953 @default.
• W2936315805 hasAuthorship W2936315805A5046158954 @default.
• W2936315805 hasAuthorship W2936315805A5050859911 @default.
• W2936315805 hasAuthorship W2936315805A5054278526 @default.
• W2936315805 hasAuthorship W2936315805A5059285590 @default.
• W2936315805 hasAuthorship W2936315805A5062517466 @default.
• W2936315805 hasAuthorship W2936315805A5067042263 @default.
• W2936315805 hasAuthorship W2936315805A5075072986 @default.
• W2936315805 hasBestOaLocation W29363158051 @default.
• W2936315805 hasConcept C134018914 @default.

• next