FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936379220> ?p ?o ?g. }

• W2936379220 endingPage "S327" @default.
• W2936379220 startingPage "S327" @default.
• W2936379220 abstract "Purpose: Previously, we identified a significant association between baseline meniscal extrusion and the short-term incidence of knee osteoarthritis (KOA). To validate these findings, we now evaluated the long-term incidence of KOA in knees with baseline meniscal extrusion, using two different cohorts. Methods: We used data from the PROOF study, a preventive RCT which evaluated a high-risk population of 407 middle-aged overweight women (BMI ≥ 27 kg/m2), and a subcohort of the Rotterdam Study (RS), a prospective population-based cohort study. Meniscal extrusion was defined as grade 2 or 3 according to the MOAKS criteria (≥ 3 mm). The primary outcome measure was incident radiographic or clinical KOA, assessed at 6.6 years (PROOF) and 5.1 years (RS). Radiographic incidence was defined as Kellgren and Lawrence (KL) ≥ grade 2 in knees with KL < 2 at baseline. Incident clinical KOA was defined fulfilling the ACR criteria at follow-up, without clinical KOA at baseline. With generalized estimating equations, we determined the association of knees with and without baseline meniscal extrusion and incident KOA, adjusted for the baseline differences. Furthermore, we computed the population attributable risk percentage (PAR%) of meniscal extrusion for both outcomes in both cohorts. Results: In PROOF, 437 knees were available for analysis of which 23% had baseline meniscal extrusion. There were statistically significant baseline differences between knees with and without meniscal extrusion regarding age, history of knee injury, varus alignment, strength quadriceps muscle, Heberden’s nodes, osteophytes, bone marrow lesions (BML) and meniscal pathologies. Incident radiographic KOA after 6.6 years was borderline significantly higher in knees with meniscal extrusion compared to those without (31% vs. 10%, adjusted OR 1.95, 95% CI 0.95, 3.98, PAR 11%). Incident clinical KOA was significantly higher (25% vs. 14%, adjusted OR 2.33, 95% CI 1.19, 4.59, PAR 18%). In the RS cohort, 890 knees were available for analysis of which 46% had baseline meniscal extrusion. There were significant baseline differences regarding BML, osteophytes and meniscal pathologies. Incidence of radiographic KOA after 5.1 years was significantly higher in knees with extrusion (8% vs 2%, adjusted OR 2.54, 95% CI 1.12, 5.76, PAR 30%). Incidence of clinical KOA was borderline significantly higher (6% vs. 2%, adjusted OR 2.05, 95% CI 0.9, 4.65, PAR 31%). Conclusions: Baseline meniscal extrusion is largely independently associated with the long-term incidence of both radiographic and clinical KOA, providing validation for our previous results after short-term follow-up. A high number of incident cases were attributable to meniscal extrusion." @default.
• W2936379220 created "2019-04-25" @default.
• W2936379220 creator A5014675252 @default.
• W2936379220 creator A5024991733 @default.
• W2936379220 creator A5043214094 @default.
• W2936379220 creator A5043266496 @default.
• W2936379220 creator A5052856573 @default.
• W2936379220 creator A5070446099 @default.
• W2936379220 date "2019-04-01" @default.
• W2936379220 modified "2023-10-16" @default.
• W2936379220 title "Association between baseline meniscal extrusion on MRI and long-term incident knee osteoarthritis in two different cohorts" @default.
• W2936379220 doi "https://doi.org/10.1016/j.joca.2019.02.732" @default.
• W2936379220 hasPublicationYear "2019" @default.
• W2936379220 type Work @default.
• W2936379220 sameAs 2936379220 @default.
• W2936379220 citedByCount "0" @default.
• W2936379220 crossrefType "journal-article" @default.
• W2936379220 hasAuthorship W2936379220A5014675252 @default.
• W2936379220 hasAuthorship W2936379220A5024991733 @default.
• W2936379220 hasAuthorship W2936379220A5043214094 @default.
• W2936379220 hasAuthorship W2936379220A5043266496 @default.
• W2936379220 hasAuthorship W2936379220A5052856573 @default.
• W2936379220 hasAuthorship W2936379220A5070446099 @default.
• W2936379220 hasBestOaLocation W29363792201 @default.
• W2936379220 hasConcept C120665830 @default.
• W2936379220 hasConcept C121332964 @default.
• W2936379220 hasConcept C126322002 @default.
• W2936379220 hasConcept C141071460 @default.
• W2936379220 hasConcept C142724271 @default.
• W2936379220 hasConcept C188816634 @default.
• W2936379220 hasConcept C201903717 @default.
• W2936379220 hasConcept C204452808 @default.
• W2936379220 hasConcept C204787440 @default.
• W2936379220 hasConcept C2776164576 @default.
• W2936379220 hasConcept C2780221984 @default.
• W2936379220 hasConcept C2780586474 @default.
• W2936379220 hasConcept C2908647359 @default.
• W2936379220 hasConcept C61511704 @default.
• W2936379220 hasConcept C71924100 @default.
• W2936379220 hasConcept C72563966 @default.
• W2936379220 hasConcept C99454951 @default.
• W2936379220 hasConceptScore W2936379220C120665830 @default.
• W2936379220 hasConceptScore W2936379220C121332964 @default.
• W2936379220 hasConceptScore W2936379220C126322002 @default.
• W2936379220 hasConceptScore W2936379220C141071460 @default.
• W2936379220 hasConceptScore W2936379220C142724271 @default.
• W2936379220 hasConceptScore W2936379220C188816634 @default.
• W2936379220 hasConceptScore W2936379220C201903717 @default.
• W2936379220 hasConceptScore W2936379220C204452808 @default.
• W2936379220 hasConceptScore W2936379220C204787440 @default.
• W2936379220 hasConceptScore W2936379220C2776164576 @default.
• W2936379220 hasConceptScore W2936379220C2780221984 @default.
• W2936379220 hasConceptScore W2936379220C2780586474 @default.
• W2936379220 hasConceptScore W2936379220C2908647359 @default.
• W2936379220 hasConceptScore W2936379220C61511704 @default.
• W2936379220 hasConceptScore W2936379220C71924100 @default.
• W2936379220 hasConceptScore W2936379220C72563966 @default.
• W2936379220 hasConceptScore W2936379220C99454951 @default.
• W2936379220 hasLocation W29363792201 @default.
• W2936379220 hasOpenAccess W2936379220 @default.
• W2936379220 hasPrimaryLocation W29363792201 @default.
• W2936379220 hasRelatedWork W170556918 @default.
• W2936379220 hasRelatedWork W2063325699 @default.
• W2936379220 hasRelatedWork W2093301149 @default.
• W2936379220 hasRelatedWork W2104267897 @default.
• W2936379220 hasRelatedWork W2123900064 @default.
• W2936379220 hasRelatedWork W2125544055 @default.
• W2936379220 hasRelatedWork W2402943696 @default.
• W2936379220 hasRelatedWork W2556102127 @default.
• W2936379220 hasRelatedWork W3010418487 @default.
• W2936379220 hasRelatedWork W4310555330 @default.
• W2936379220 hasVolume "27" @default.
• W2936379220 isParatext "false" @default.
• W2936379220 isRetracted "false" @default.
• W2936379220 magId "2936379220" @default.
• W2936379220 workType "article" @default.