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- W2936384170 abstract "Injectable biopolymer hydrogels have gained attention for use as scaffolds to promote cardiac function and prevent negative left ventricular (LV) remodeling post-myocardial infarction (MI). However, most hydrogels tested in preclinical studies are not candidates for minimally invasive catheter delivery due to excess material viscosity, rapid gelation times, and/or concerns regarding hemocompatibility and potential for embolism. We describe a platform technology for progelator materials formulated as sterically constrained cyclic peptides which flow freely for low resistance injection, and rapidly assemble into hydrogels when linearized by disease-associated enzymes. Their utility in vivo is demonstrated by their ability to flow through a syringe and gel at the site of MI in rat models. Additionally, synthetic functionalization enables these materials to flow through a cardiac injection catheter without clogging, without compromising hemocompatibility or cytotoxicity. These studies set the stage for the development of structurally dynamic biomaterials for therapeutic hydrogel delivery to the MI." @default.
- W2936384170 created "2019-04-25" @default.
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- W2936384170 date "2019-04-15" @default.
- W2936384170 modified "2023-10-16" @default.
- W2936384170 title "Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction" @default.
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- W2936384170 doi "https://doi.org/10.1038/s41467-019-09587-y" @default.
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