FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936389616> ?p ?o ?g. }

• W2936389616 abstract "'Bianliang ziyu', a famous chrysanthemum variety commonly planted in Kaifeng, China, is often consumed by local residents. However, the hepatoprotective effects of Bianliang ziyu and their underlying mechanisms are not clear.In this study, we investigated the hepatoprotective and antioxidative effects of Bianliang ziyu extract (BZE) on liver injury and explored its molecular mechanisms.Sprague-Dawley rats were administered BZE by intragastric administration for 8-9 days, and then alcohol or carbon tetrachloride (CCl4) was administered by gavage to induce acute liver injury. The activities of serum alanine aminotransferase, aspartate aminotransferase, superoxide dismutase, and malondialdehyde in the rats were measured, and the liver of each rat was examined for histopathological changes. In vitro, HL-7702 cells were pretreated with BZE for 24 h and then exposed to 30 mmol•L-1 acetaminophen (APAP) for 12 h. The survival rate of the cells and the alanine aminotransferase and aspartate aminotransferase activities were determined. Then, we investigated the effects of BZE on oxidative stress, apoptosis, and the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) signaling in HL-7702 cells induced by APAP.The results showed that BZE prevented alcohol-, CCl4-, and APAP-induced liver injury and suppressed hepatic oxidative stress in vitro and in vivo. BZE was also observed to significantly inhibit the reduction of mitochondrial membrane potential and regulate the expression of Bcl-2, Bax and Caspase-3 in APAP-induced HL-7702 cells. In addition, BZE significantly promoted nuclear translocation and the expression of Nrf2 as well as its downstream gene hemeoxygenase-1 (HO-1) in vitro. Furthermore, the findings showed that Nrf2 siRNA reversed the effects of BZE on cell survival and apoptosis-related protein expression in APAP-induced HL-7702 cells.BZE plays an important role in preventing hepatotoxicity by inhibiting oxidative stress and apoptosis through activation of Nrf2 signaling. BZE could be developed as an effective functional food for protecting the liver." @default.
• W2936389616 created "2019-04-25" @default.
• W2936389616 creator A5008645875 @default.
• W2936389616 creator A5011916760 @default.
• W2936389616 creator A5016152357 @default.
• W2936389616 creator A5024290465 @default.
• W2936389616 creator A5033735272 @default.
• W2936389616 creator A5036647389 @default.
• W2936389616 creator A5045455104 @default.
• W2936389616 creator A5077163282 @default.
• W2936389616 creator A5084888732 @default.
• W2936389616 creator A5086066895 @default.
• W2936389616 date "2019-04-15" @default.
• W2936389616 modified "2023-09-24" @default.
• W2936389616 title "Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro" @default.
• W2936389616 cites W1261162265 @default.
• W2936389616 cites W1421415727 @default.
• W2936389616 cites W1966306037 @default.
• W2936389616 cites W1974638953 @default.
• W2936389616 cites W1975670490 @default.
• W2936389616 cites W1978481215 @default.
• W2936389616 cites W1997242730 @default.
• W2936389616 cites W2003867270 @default.
• W2936389616 cites W2021156668 @default.
• W2936389616 cites W2033174557 @default.
• W2936389616 cites W2044155459 @default.
• W2936389616 cites W2046266642 @default.
• W2936389616 cites W2046599121 @default.
• W2936389616 cites W2057965330 @default.
• W2936389616 cites W2067008795 @default.
• W2936389616 cites W2072047912 @default.
• W2936389616 cites W2074973696 @default.
• W2936389616 cites W2087714907 @default.
• W2936389616 cites W2111017693 @default.
• W2936389616 cites W2123273533 @default.
• W2936389616 cites W2124728669 @default.
• W2936389616 cites W2132505029 @default.
• W2936389616 cites W2157626574 @default.
• W2936389616 cites W2190826983 @default.
• W2936389616 cites W2221338781 @default.
• W2936389616 cites W2557438775 @default.
• W2936389616 cites W2604323436 @default.
• W2936389616 cites W2609731130 @default.
• W2936389616 cites W2609889280 @default.
• W2936389616 cites W2611028551 @default.
• W2936389616 cites W2669457690 @default.
• W2936389616 cites W2739819331 @default.
• W2936389616 cites W2754296049 @default.
• W2936389616 cites W2765395475 @default.
• W2936389616 cites W2766302604 @default.
• W2936389616 cites W2766582365 @default.
• W2936389616 cites W2769517954 @default.
• W2936389616 cites W2781558134 @default.
• W2936389616 cites W2781561616 @default.
• W2936389616 cites W2783493404 @default.
• W2936389616 cites W2784143867 @default.
• W2936389616 cites W2790222047 @default.
• W2936389616 cites W2790658248 @default.
• W2936389616 cites W2790789634 @default.
• W2936389616 cites W2790829602 @default.
• W2936389616 cites W2791045836 @default.
• W2936389616 cites W2791513217 @default.
• W2936389616 cites W2791907796 @default.
• W2936389616 cites W2793239171 @default.
• W2936389616 cites W2793484183 @default.
• W2936389616 cites W2796037841 @default.
• W2936389616 cites W2796461907 @default.
• W2936389616 cites W2802371735 @default.
• W2936389616 cites W2802946850 @default.
• W2936389616 cites W2883197823 @default.
• W2936389616 cites W379961867 @default.
• W2936389616 cites W4250437686 @default.
• W2936389616 cites W4404447 @default.
• W2936389616 doi "https://doi.org/10.29219/fnr.v63.1667" @default.
• W2936389616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6475127" @default.
• W2936389616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31024225" @default.
• W2936389616 hasPublicationYear "2019" @default.
• W2936389616 type Work @default.
• W2936389616 sameAs 2936389616 @default.
• W2936389616 citedByCount "19" @default.
• W2936389616 countsByYear W29363896162020 @default.
• W2936389616 countsByYear W29363896162021 @default.
• W2936389616 countsByYear W29363896162022 @default.
• W2936389616 countsByYear W29363896162023 @default.
• W2936389616 crossrefType "journal-article" @default.
• W2936389616 hasAuthorship W2936389616A5008645875 @default.
• W2936389616 hasAuthorship W2936389616A5011916760 @default.
• W2936389616 hasAuthorship W2936389616A5016152357 @default.
• W2936389616 hasAuthorship W2936389616A5024290465 @default.
• W2936389616 hasAuthorship W2936389616A5033735272 @default.
• W2936389616 hasAuthorship W2936389616A5036647389 @default.
• W2936389616 hasAuthorship W2936389616A5045455104 @default.
• W2936389616 hasAuthorship W2936389616A5077163282 @default.
• W2936389616 hasAuthorship W2936389616A5084888732 @default.
• W2936389616 hasAuthorship W2936389616A5086066895 @default.
• W2936389616 hasBestOaLocation W29363896161 @default.
• W2936389616 hasConcept C150903083 @default.
• W2936389616 hasConcept C178790620 @default.
• W2936389616 hasConcept C185592680 @default.
• W2936389616 hasConcept C190283241 @default.

• next