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• W2936402931 abstract "Localized, oscillating Ca2+ signals have been identified in discrete microdomains of vascular endothelial cells. At myoendothelial contacts (between endothelial and smooth muscle cells), both endothelial Ca2+ pulsars (IP3-mediated release of intracellular Ca2+) and Ca2+ sparklets (extracellular Ca2+ entry via TRP channels) contribute to endothelium-dependent hyperpolarization of smooth muscle, vasodilation, and feedback control of vasoconstriction. Ca2+ sparklets occurring at close-contact domains between endothelial cells are possibly involved in conducted hyperpolarization and spreading vasodilation in arterial networks. This review summarizes these Ca2+ signalling phenomena, examines the proposed mechanisms leading to their generation by G-protein-coupled receptor agonists, and explores the proposed physiological roles of these localized and specialized Ca2+ signals." @default.
• W2936402931 created "2019-04-25" @default.
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• W2936402931 date "2019-04-01" @default.
• W2936402931 modified "2023-09-25" @default.
• W2936402931 title "Agonist-evoked endothelial Ca2+ signalling microdomains" @default.
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• W2936402931 doi "https://doi.org/10.1016/j.coph.2019.03.005" @default.
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