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• W2936403042 endingPage "3064" @default.
• W2936403042 startingPage "3053" @default.
• W2936403042 abstract "Acute graft-versus-host disease (aGVHD) hinders the efficacy of allogeneic hematopoietic cell transplantation (HCT). Plasma levels of soluble membrane-bound ST2 (ST2) are elevated in human and murine aGVHD and correlated to type 1 T cells response. ST2 signals through the adapter protein MyD88. The role of MyD88 in T cells during aGVHD has yet to be elucidated. We found that knocking out MyD88 in the donor T cells protected against aGVHD independent of IL-1R and TLR4 signaling in two murine HCT models. This protection was entirely driven by MyD88-/- CD4 T cells. Transplanting donor MyD88-/- conventional T cells (Tcons) with wild-type (WT) or MyD88-/- regulatory T cells (Tregs) lowered aGVHD severity and mortality. Transcriptome analysis of sorted MyD88-/- CD4 T cells from the intestine 10 d post-HCT showed lower levels of Il1rl1 (gene of ST2), Ifng, Csf2, Stat5, Batf, and Jak2 Transplanting donor ST2-/- Tcons with WT or ST2-/- Tregs showed a similar phenotype with what we observed when using donor MyD88-/- Tcons. Decreased ST2 was confirmed at the protein level with less secretion of soluble ST2 and more expression of ST2 compared with WT T cells. Our data suggest that Treg suppression from lack of MyD88 signaling in donor Tcons during alloreactivity uses the ST2 but not the IL-1R or TLR4 pathways, and ST2 represents a potential aGVHD therapeutic target sparing Tregs." @default.
• W2936403042 created "2019-04-25" @default.
• W2936403042 creator A5018888214 @default.
• W2936403042 creator A5030843866 @default.
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• W2936403042 creator A5084306160 @default.
• W2936403042 date "2019-05-15" @default.
• W2936403042 modified "2023-09-27" @default.
• W2936403042 title "ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells" @default.
• W2936403042 cites W118616534 @default.
• W2936403042 cites W1492672904 @default.
• W2936403042 cites W1525912444 @default.
• W2936403042 cites W1535492142 @default.
• W2936403042 cites W1572508860 @default.
• W2936403042 cites W1596317162 @default.
• W2936403042 cites W1631804487 @default.
• W2936403042 cites W1885121590 @default.
• W2936403042 cites W1950448919 @default.
• W2936403042 cites W1970181089 @default.
• W2936403042 cites W1970726622 @default.
• W2936403042 cites W1974092500 @default.
• W2936403042 cites W1994624777 @default.
• W2936403042 cites W1995355078 @default.
• W2936403042 cites W1999028040 @default.
• W2936403042 cites W2001316686 @default.
• W2936403042 cites W2004465286 @default.
• W2936403042 cites W2009110370 @default.
• W2936403042 cites W2009737338 @default.
• W2936403042 cites W2010175068 @default.
• W2936403042 cites W2011934933 @default.
• W2936403042 cites W2015617985 @default.
• W2936403042 cites W2023560778 @default.
• W2936403042 cites W2024060364 @default.
• W2936403042 cites W2028489100 @default.
• W2936403042 cites W2036736974 @default.
• W2936403042 cites W2039839084 @default.
• W2936403042 cites W2047784590 @default.
• W2936403042 cites W2051887848 @default.
• W2936403042 cites W2055677239 @default.
• W2936403042 cites W2056991195 @default.
• W2936403042 cites W2057121293 @default.
• W2936403042 cites W2065617024 @default.
• W2936403042 cites W2068322448 @default.
• W2936403042 cites W2070321412 @default.
• W2936403042 cites W2073282068 @default.
• W2936403042 cites W2084575069 @default.
• W2936403042 cites W2091880606 @default.
• W2936403042 cites W2092713406 @default.
• W2936403042 cites W2102821093 @default.
• W2936403042 cites W2105179089 @default.
• W2936403042 cites W2107369528 @default.
• W2936403042 cites W2112966339 @default.
• W2936403042 cites W2120031234 @default.
• W2936403042 cites W2123833754 @default.
• W2936403042 cites W2125823507 @default.
• W2936403042 cites W2131766513 @default.
• W2936403042 cites W2134138119 @default.
• W2936403042 cites W2136158798 @default.
• W2936403042 cites W2136268380 @default.
• W2936403042 cites W2139823699 @default.
• W2936403042 cites W2143168086 @default.
• W2936403042 cites W2144491171 @default.
• W2936403042 cites W2145164170 @default.
• W2936403042 cites W2145708130 @default.
• W2936403042 cites W2145866317 @default.
• W2936403042 cites W2146496194 @default.
• W2936403042 cites W2155432151 @default.
• W2936403042 cites W2157710399 @default.
• W2936403042 cites W2158932972 @default.
• W2936403042 cites W2159322723 @default.
• W2936403042 cites W2161152348 @default.
• W2936403042 cites W2161290719 @default.
• W2936403042 cites W2161903097 @default.
• W2936403042 cites W2167996547 @default.
• W2936403042 cites W2172471314 @default.
• W2936403042 cites W2175868602 @default.
• W2936403042 cites W2191555067 @default.
• W2936403042 cites W2343474857 @default.
• W2936403042 cites W2396827761 @default.
• W2936403042 cites W2400446541 @default.
• W2936403042 cites W2405227830 @default.
• W2936403042 cites W2509961279 @default.
• W2936403042 cites W2518809562 @default.
• W2936403042 cites W2536800637 @default.
• W2936403042 cites W2554783736 @default.
• W2936403042 cites W2557740095 @default.
• W2936403042 cites W2570737147 @default.
• W2936403042 cites W2579912490 @default.
• W2936403042 cites W2582648781 @default.
• W2936403042 cites W2586256617 @default.
• W2936403042 cites W2609744794 @default.
• W2936403042 cites W2634993714 @default.
• W2936403042 cites W2739736711 @default.
• W2936403042 cites W2766957369 @default.

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