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- W2936576316 abstract "Understanding mechanisms of chemotherapy cardiotoxicity is an important problem due to the lack of clear understanding of its occurrence. Development of endothelial dysfunction is considered to be one of possible ways in implementation of these side effects. The analysis of endothelin-1 and e-selectin levels in 26 patients with lymphoproliferative diseases before and after the completion of the treatment program was been performed. The results of the study showed normal values of E-selectin level and increased level of endothelin-1 in the whole group of patients before treatment. After completion of chemotherapy program, in the whole group, there was a decrease of these two markers. However, values of level of endothelin-1 with vasoconstrictor effect remained high even after the end of therapy. It is imp ortant that at detailed analysis the dynamics of investigated markers in patients of older age group (median age 64 years) was associated with worsening of endothelial dysfunction." @default.
- W2936576316 created "2019-04-25" @default.
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- W2936576316 date "2019-04-18" @default.
- W2936576316 modified "2023-10-05" @default.
- W2936576316 title "The Role of Endothelial Dysfunction in the Development of Cardiotoxic Action of Cytostatics in Patients with Lymphoproliferative Diseases" @default.
- W2936576316 cites W2089055004 @default.
- W2936576316 cites W2147646179 @default.
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- W2936576316 doi "https://doi.org/10.18087/cardio.2019.4.10251" @default.
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