Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936579903> ?p ?o ?g. }
- W2936579903 abstract "The field of HIV research relies heavily on non-human primates, particularly the members of the macaque genus, as models for the evaluation of candidate vaccines and monoclonal antibodies. A growing body of research suggests that successful protection of humans will not solely rely on the neutralization activity of an antibody's antigen binding fragment. Rather, immunological effector functions prompted by the interaction of the immunoglobulin G constant region and its cognate Fc receptors help contribute to favorable outcomes. Inherent differences in the sequences, expression, and activities of human and non-human primate antibody receptors and immunoglobulins have the potential to produce disparate results in the observations made in studies conducted in differing species. Having a more complete understanding of these differences, however, should permit the more fluent translation of observations between model organisms and the clinic. Here we present a guide to such translations that encompasses not only what is presently known regarding the affinity of the receptor-ligand interactions but also the influence of expression patterns and allelic variation, with a focus on insights gained from use of this model in HIV vaccines and passive antibody therapy and treatment." @default.
- W2936579903 created "2019-04-25" @default.
- W2936579903 creator A5027226086 @default.
- W2936579903 creator A5071990559 @default.
- W2936579903 date "2019-04-08" @default.
- W2936579903 modified "2023-10-17" @default.
- W2936579903 title "Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function" @default.
- W2936579903 cites W1484884286 @default.
- W2936579903 cites W1502236998 @default.
- W2936579903 cites W1502725684 @default.
- W2936579903 cites W1507226598 @default.
- W2936579903 cites W1509314368 @default.
- W2936579903 cites W1510327637 @default.
- W2936579903 cites W1518617543 @default.
- W2936579903 cites W1519574375 @default.
- W2936579903 cites W1523240418 @default.
- W2936579903 cites W1527622313 @default.
- W2936579903 cites W1528520360 @default.
- W2936579903 cites W1529373421 @default.
- W2936579903 cites W1543394342 @default.
- W2936579903 cites W1550598557 @default.
- W2936579903 cites W1552653926 @default.
- W2936579903 cites W1565404266 @default.
- W2936579903 cites W1565933769 @default.
- W2936579903 cites W1571049310 @default.
- W2936579903 cites W1580163717 @default.
- W2936579903 cites W1580912180 @default.
- W2936579903 cites W1586476245 @default.
- W2936579903 cites W1592000292 @default.
- W2936579903 cites W1600685634 @default.
- W2936579903 cites W1602466188 @default.
- W2936579903 cites W1608772801 @default.
- W2936579903 cites W1623081601 @default.
- W2936579903 cites W165036993 @default.
- W2936579903 cites W1656961899 @default.
- W2936579903 cites W1670077883 @default.
- W2936579903 cites W1686249017 @default.
- W2936579903 cites W176519901 @default.
- W2936579903 cites W1838210676 @default.
- W2936579903 cites W1887985700 @default.
- W2936579903 cites W1888221672 @default.
- W2936579903 cites W1893571729 @default.
- W2936579903 cites W1895264329 @default.
- W2936579903 cites W1922278110 @default.
- W2936579903 cites W1939063197 @default.
- W2936579903 cites W1951663525 @default.
- W2936579903 cites W1960158273 @default.
- W2936579903 cites W1963979508 @default.
- W2936579903 cites W1965962344 @default.
- W2936579903 cites W1970020409 @default.
- W2936579903 cites W1971041641 @default.
- W2936579903 cites W1974049689 @default.
- W2936579903 cites W1975039969 @default.
- W2936579903 cites W1975873947 @default.
- W2936579903 cites W1976394313 @default.
- W2936579903 cites W1977711336 @default.
- W2936579903 cites W1979865362 @default.
- W2936579903 cites W1980655909 @default.
- W2936579903 cites W1983310339 @default.
- W2936579903 cites W1985136634 @default.
- W2936579903 cites W1986652140 @default.
- W2936579903 cites W1986864699 @default.
- W2936579903 cites W1991656907 @default.
- W2936579903 cites W1994744932 @default.
- W2936579903 cites W1994805857 @default.
- W2936579903 cites W2001979593 @default.
- W2936579903 cites W2004290717 @default.
- W2936579903 cites W2004884319 @default.
- W2936579903 cites W2005320015 @default.
- W2936579903 cites W2008602151 @default.
- W2936579903 cites W2008977680 @default.
- W2936579903 cites W2012967644 @default.
- W2936579903 cites W2013048749 @default.
- W2936579903 cites W2013321603 @default.
- W2936579903 cites W2019372488 @default.
- W2936579903 cites W2019846395 @default.
- W2936579903 cites W2021374814 @default.
- W2936579903 cites W2023024432 @default.
- W2936579903 cites W2024608724 @default.
- W2936579903 cites W2025012298 @default.
- W2936579903 cites W2027993940 @default.
- W2936579903 cites W2029850226 @default.
- W2936579903 cites W2030129290 @default.
- W2936579903 cites W2031564934 @default.
- W2936579903 cites W2034148546 @default.
- W2936579903 cites W2034391988 @default.
- W2936579903 cites W2035151062 @default.
- W2936579903 cites W2035464330 @default.
- W2936579903 cites W2036278920 @default.
- W2936579903 cites W2037007095 @default.
- W2936579903 cites W2038319340 @default.
- W2936579903 cites W2042555734 @default.
- W2936579903 cites W2042864471 @default.
- W2936579903 cites W2043279147 @default.
- W2936579903 cites W2044538137 @default.
- W2936579903 cites W2045136276 @default.
- W2936579903 cites W2047659977 @default.
- W2936579903 cites W2048504768 @default.
- W2936579903 cites W2049625674 @default.
- W2936579903 cites W2050125448 @default.