FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936601462> ?p ?o ?g. }

• W2936601462 abstract "therapeutic monitoring of anti-TNF drugs and anti-drug antibody levels are useful for clinical decision-making, via the rationalization and optimization of the use of anti-TNF treatments. The objective of the present study was to validate the model of Ternant et al., in a cohort of patients with inflammatory bowel diseases (IBD). This model was originally established for patients with rheumatoid arthritis and was used in this study to optimize the adalimumab (ADA) dose and predict ADA trough levels (ATL).this study used concentration data points from 30 IBD patients who received ADA treatment between 2014 and 2015. A goodness-of-fit of the model was determined by evaluating the relationship between the observed ATL values and population model-predicted values (PRED) or individual model-predicted values (IPRED).a total of 51 ADA concentration points were analyzed. The bias of the model was 2.39 (95% CI, 1.63-3.15) for PRED and 0.63 (95% CI, 0.23-1.03) for IPRED. The precision was 3.57 (95% CI, 2.90-4.13) and 1.53 (95% CI, 1.22-1.80), respectively.therapeutic drug monitoring involving ATL may allow the optimization of the treatment of IBD patients. The validation results of the phamacokinectic (PK) model for ADA in IBD patients are inadequate. However, additional studies will strengthen the bias and precision of the model." @default.
• W2936601462 created "2019-04-25" @default.
• W2936601462 creator A5006341310 @default.
• W2936601462 creator A5009138858 @default.
• W2936601462 creator A5011913306 @default.
• W2936601462 creator A5015768764 @default.
• W2936601462 creator A5032227593 @default.
• W2936601462 creator A5057657752 @default.
• W2936601462 creator A5064434395 @default.
• W2936601462 creator A5077755126 @default.
• W2936601462 creator A5087180971 @default.
• W2936601462 date "2019-01-01" @default.
• W2936601462 modified "2023-10-10" @default.
• W2936601462 title "Validation of a population pharmacokinetic model of adalimumab in a cohort of patients with inflammatory bowel disease" @default.
• W2936601462 cites W1561994144 @default.
• W2936601462 cites W1575586478 @default.
• W2936601462 cites W1602142879 @default.
• W2936601462 cites W163800411 @default.
• W2936601462 cites W1940760407 @default.
• W2936601462 cites W1969084658 @default.
• W2936601462 cites W1984814995 @default.
• W2936601462 cites W1992035731 @default.
• W2936601462 cites W1994479450 @default.
• W2936601462 cites W1995529175 @default.
• W2936601462 cites W1996472975 @default.
• W2936601462 cites W1997999969 @default.
• W2936601462 cites W2000739170 @default.
• W2936601462 cites W2003143162 @default.
• W2936601462 cites W2003904406 @default.
• W2936601462 cites W2009025779 @default.
• W2936601462 cites W2022413885 @default.
• W2936601462 cites W2030638161 @default.
• W2936601462 cites W2034939253 @default.
• W2936601462 cites W2044160586 @default.
• W2936601462 cites W2065616659 @default.
• W2936601462 cites W2076523377 @default.
• W2936601462 cites W2085949689 @default.
• W2936601462 cites W2088135039 @default.
• W2936601462 cites W2092863985 @default.
• W2936601462 cites W2117212747 @default.
• W2936601462 cites W2118088660 @default.
• W2936601462 cites W2118559127 @default.
• W2936601462 cites W2131950421 @default.
• W2936601462 cites W2134803931 @default.
• W2936601462 cites W2147810684 @default.
• W2936601462 cites W2152353173 @default.
• W2936601462 cites W2153438195 @default.
• W2936601462 cites W2171341132 @default.
• W2936601462 cites W2290515360 @default.
• W2936601462 cites W2410520654 @default.
• W2936601462 cites W850868591 @default.
• W2936601462 doi "https://doi.org/10.17235/reed.2019.5600/2018" @default.
• W2936601462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31021170" @default.
• W2936601462 hasPublicationYear "2019" @default.
• W2936601462 type Work @default.
• W2936601462 sameAs 2936601462 @default.
• W2936601462 citedByCount "1" @default.
• W2936601462 countsByYear W29366014622020 @default.
• W2936601462 crossrefType "journal-article" @default.
• W2936601462 hasAuthorship W2936601462A5006341310 @default.
• W2936601462 hasAuthorship W2936601462A5009138858 @default.
• W2936601462 hasAuthorship W2936601462A5011913306 @default.
• W2936601462 hasAuthorship W2936601462A5015768764 @default.
• W2936601462 hasAuthorship W2936601462A5032227593 @default.
• W2936601462 hasAuthorship W2936601462A5057657752 @default.
• W2936601462 hasAuthorship W2936601462A5064434395 @default.
• W2936601462 hasAuthorship W2936601462A5077755126 @default.
• W2936601462 hasAuthorship W2936601462A5087180971 @default.
• W2936601462 hasBestOaLocation W29366014621 @default.
• W2936601462 hasConcept C112705442 @default.
• W2936601462 hasConcept C126322002 @default.
• W2936601462 hasConcept C2777575956 @default.
• W2936601462 hasConcept C2778260677 @default.
• W2936601462 hasConcept C2779134260 @default.
• W2936601462 hasConcept C2780132546 @default.
• W2936601462 hasConcept C2780272996 @default.
• W2936601462 hasConcept C2908647359 @default.
• W2936601462 hasConcept C71924100 @default.
• W2936601462 hasConcept C72563966 @default.
• W2936601462 hasConcept C90924648 @default.
• W2936601462 hasConcept C99454951 @default.
• W2936601462 hasConceptScore W2936601462C112705442 @default.
• W2936601462 hasConceptScore W2936601462C126322002 @default.
• W2936601462 hasConceptScore W2936601462C2777575956 @default.
• W2936601462 hasConceptScore W2936601462C2778260677 @default.
• W2936601462 hasConceptScore W2936601462C2779134260 @default.
• W2936601462 hasConceptScore W2936601462C2780132546 @default.
• W2936601462 hasConceptScore W2936601462C2780272996 @default.
• W2936601462 hasConceptScore W2936601462C2908647359 @default.
• W2936601462 hasConceptScore W2936601462C71924100 @default.
• W2936601462 hasConceptScore W2936601462C72563966 @default.
• W2936601462 hasConceptScore W2936601462C90924648 @default.
• W2936601462 hasConceptScore W2936601462C99454951 @default.
• W2936601462 hasLocation W29366014621 @default.
• W2936601462 hasLocation W29366014622 @default.
• W2936601462 hasOpenAccess W2936601462 @default.
• W2936601462 hasPrimaryLocation W29366014621 @default.
• W2936601462 hasRelatedWork W2156283049 @default.
• W2936601462 hasRelatedWork W2316954211 @default.
• W2936601462 hasRelatedWork W2326094713 @default.

• next