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- W2936614919 endingPage "137" @default.
- W2936614919 startingPage "116" @default.
- W2936614919 abstract "Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells recycle or degrades internal constituents through membrane-trafficking pathway. Thus, autophagy provides the cells with a sustainable source of biomolecules and energy for the maintenance of homeostasis under stressful conditions such as tumor microenvironment. Recent findings revealed a close relationship between autophagy and malignant transformation. However, due to the complex dual role of autophagy in tumor survival or cell death, efforts to develop efficient treatment strategies targeting the autophagy/cancer relation have largely been unsuccessful. Here we review the two-faced role of autophagy in cancer as a tumor suppressor or as a pro-oncogenic mechanism. In this sense, we also review the shared regulatory pathways that play a role in autophagy and malignant transformation. Finally, anti-cancer therapeutic agents used as either inhibitors or inducers of autophagy have been discussed." @default.
- W2936614919 created "2019-04-25" @default.
- W2936614919 creator A5011674008 @default.
- W2936614919 creator A5025831398 @default.
- W2936614919 creator A5033302964 @default.
- W2936614919 creator A5036662897 @default.
- W2936614919 creator A5041160545 @default.
- W2936614919 creator A5046898644 @default.
- W2936614919 date "2019-06-01" @default.
- W2936614919 modified "2023-10-17" @default.
- W2936614919 title "Autophagy as a molecular target for cancer treatment" @default.
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