FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936615092> ?p ?o ?g. }

• W2936615092 endingPage "101195" @default.
• W2936615092 startingPage "101195" @default.
• W2936615092 abstract "Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exert a protective role in renal I/R injury in mice. Inhibiting Brd4 with either JQ1 or genetic knockdown resulted in reduction of endoplasmic reticulum stress (ERS)-associated protein and proapoptotic protein expression both in I/R-induced injury and hypoxia/reoxygenation (H/R) stimulation in HK-2 cells. H/R-induced apoptosis and ERS depended on oxidative stress in vitro. Moreover, FoxO4, which is involved in the generation of hydrogen peroxide, was up-regulated during H/R stimulation-mediated apoptosis and ERS, and this upregulation could be abolished by Brd4 inhibition. Consistently, FoxO4-mediated ROS generation was attenuated upon inhibition of Brd4 with JQ1 or siRNA against Brd4. Further, the transcriptional activity of FoxO4 was suppressed by PI3K and AKT phosphorylation, which are upstream signals of FoxO4 expression, and were enhanced by Brd4 both in vivo and in vitro. In conclusion, our results proved that Brd4 inhibition blocked renal apoptotic and ERS protein expression by preventing FoxO4-dependent ROS generation through the PI3K/AKT pathway, indicating that Brd4 could be a potential therapeutic target for renal I/R injury." @default.
• W2936615092 created "2019-04-25" @default.
• W2936615092 creator A5011090841 @default.
• W2936615092 creator A5054268541 @default.
• W2936615092 creator A5060717982 @default.
• W2936615092 creator A5073216396 @default.
• W2936615092 creator A5074480744 @default.
• W2936615092 creator A5074754590 @default.
• W2936615092 creator A5082561285 @default.
• W2936615092 creator A5088664989 @default.
• W2936615092 date "2019-06-01" @default.
• W2936615092 modified "2023-10-14" @default.
• W2936615092 title "Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress" @default.
• W2936615092 cites W1539621112 @default.
• W2936615092 cites W1965764533 @default.
• W2936615092 cites W1979012323 @default.
• W2936615092 cites W1981385339 @default.
• W2936615092 cites W1982085112 @default.
• W2936615092 cites W1988503641 @default.
• W2936615092 cites W1991719590 @default.
• W2936615092 cites W2005003726 @default.
• W2936615092 cites W2012317303 @default.
• W2936615092 cites W2033394110 @default.
• W2936615092 cites W2037896546 @default.
• W2936615092 cites W2041325378 @default.
• W2936615092 cites W2041535798 @default.
• W2936615092 cites W2057247058 @default.
• W2936615092 cites W2067463198 @default.
• W2936615092 cites W2079723429 @default.
• W2936615092 cites W2088442622 @default.
• W2936615092 cites W2092248444 @default.
• W2936615092 cites W2114371777 @default.
• W2936615092 cites W2118428599 @default.
• W2936615092 cites W2126112553 @default.
• W2936615092 cites W2134163902 @default.
• W2936615092 cites W2139832080 @default.
• W2936615092 cites W2162695817 @default.
• W2936615092 cites W2164965999 @default.
• W2936615092 cites W2170597525 @default.
• W2936615092 cites W2208910479 @default.
• W2936615092 cites W2306448172 @default.
• W2936615092 cites W2411070120 @default.
• W2936615092 cites W2532339529 @default.
• W2936615092 cites W2562640620 @default.
• W2936615092 cites W2725175470 @default.
• W2936615092 cites W2739941486 @default.
• W2936615092 cites W2790847363 @default.
• W2936615092 cites W2799813921 @default.
• W2936615092 cites W2888373402 @default.
• W2936615092 cites W2982113259 @default.
• W2936615092 cites W2995228298 @default.
• W2936615092 doi "https://doi.org/10.1016/j.redox.2019.101195" @default.
• W2936615092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6475721" @default.
• W2936615092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31004990" @default.
• W2936615092 hasPublicationYear "2019" @default.
• W2936615092 type Work @default.
• W2936615092 sameAs 2936615092 @default.
• W2936615092 citedByCount "116" @default.
• W2936615092 countsByYear W29366150922019 @default.
• W2936615092 countsByYear W29366150922020 @default.
• W2936615092 countsByYear W29366150922021 @default.
• W2936615092 countsByYear W29366150922022 @default.
• W2936615092 countsByYear W29366150922023 @default.
• W2936615092 crossrefType "journal-article" @default.
• W2936615092 hasAuthorship W2936615092A5011090841 @default.
• W2936615092 hasAuthorship W2936615092A5054268541 @default.
• W2936615092 hasAuthorship W2936615092A5060717982 @default.
• W2936615092 hasAuthorship W2936615092A5073216396 @default.
• W2936615092 hasAuthorship W2936615092A5074480744 @default.
• W2936615092 hasAuthorship W2936615092A5074754590 @default.
• W2936615092 hasAuthorship W2936615092A5082561285 @default.
• W2936615092 hasAuthorship W2936615092A5088664989 @default.
• W2936615092 hasBestOaLocation W29366150921 @default.
• W2936615092 hasConcept C104317684 @default.
• W2936615092 hasConcept C127561419 @default.
• W2936615092 hasConcept C139447449 @default.
• W2936615092 hasConcept C158617107 @default.
• W2936615092 hasConcept C173396325 @default.
• W2936615092 hasConcept C185592680 @default.
• W2936615092 hasConcept C190283241 @default.
• W2936615092 hasConcept C2776151105 @default.
• W2936615092 hasConcept C502942594 @default.
• W2936615092 hasConcept C55493867 @default.
• W2936615092 hasConcept C75217442 @default.
• W2936615092 hasConcept C86554907 @default.
• W2936615092 hasConcept C86803240 @default.
• W2936615092 hasConcept C95444343 @default.
• W2936615092 hasConcept C98274493 @default.
• W2936615092 hasConceptScore W2936615092C104317684 @default.
• W2936615092 hasConceptScore W2936615092C127561419 @default.
• W2936615092 hasConceptScore W2936615092C139447449 @default.
• W2936615092 hasConceptScore W2936615092C158617107 @default.
• W2936615092 hasConceptScore W2936615092C173396325 @default.
• W2936615092 hasConceptScore W2936615092C185592680 @default.
• W2936615092 hasConceptScore W2936615092C190283241 @default.
• W2936615092 hasConceptScore W2936615092C2776151105 @default.
• W2936615092 hasConceptScore W2936615092C502942594 @default.
• W2936615092 hasConceptScore W2936615092C55493867 @default.

• next