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• W2936619557 abstract "Severe hand, foot, and mouth disease (HFMD) is a common childhood illness caused by various enteroviruses. The disease has imposed increased burden on children younger than 5 years old. We aimed to determine the epidemiology, CNS complication, and etiology among severe HFMD patients, in Jiangsu, China. Epidemiological, clinical, and laboratory data of severe HFMD cases were extracted from 2009 to 2015. The CNS complication, annually severe illness rates, mortality rates, severity-PICU admission rates, severity-hospitalization rates, and so on were analyzed to assess the disease burden of severe HFMD. All analyses were stratified by time, region, population, CNS involvement and serotypes. The VP1 gene from EV-A71, CV-A16, CV-A6, CV-A10 and other enteroviruses isolates was amplified. Phylogenetic analysis was performed using MEGA5.0. Seven thousand nine hundred ninety-four severe HFMD cases were reported, of them, 7224 cases were inpatients, 611 were PICU inpatients, and 68 were fatal. The average severe illness rate, mortality rate, severity−fatality rate, severity-PICU admission rate, and severity-hospitalization rate were 14.54, 0.12,8506, 76,430, and 903,700 per 1 million, respectively. The severe illness rate was the highest in the 12–23 months age group, and the greatest mortality rate was in the 6–11 months age group. Geographical difference in severe illness rate and mortality were found. Patients infected with EV-A71 were at a higher proportion in different CNS involvement even death. EV-A71, CV-A16 and other enteroviruses accounted for 79.14, 6.49, and 14.47%, respectively. A total of 14 non-EV-A71/ CV-A16 genotypes including CV-A2, CV-A4, CV-A 6, CV-A9, CV-A10, CV-B1, CV-B2, CV-B3, CV-B4, CV-B5, E-6, E-7, E-18, and EV-C96 were identified. Phylogentic analyses demonstrated that EV-A71 strains belonged to subgenotype C4a, while CV-A16 strains belonged to sub-genotype B1a and sub-genotype B1b of genotype B1. CV-A6 strains were assigned to genogroup F, and CV-A10 strains belonged to genogroup D. Future mitigation policies should take into account the age, region heterogeneities, CNS conditions and serotype of disease. Additional a more rigorous study between the mild and severe HFMD should be warranted to elucidate the difference epidemiology, pathogen spectrum and immunity patterns and to optimize interventions in the following study." @default.
• W2936619557 created "2019-04-25" @default.
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• W2936619557 date "2019-01-22" @default.
• W2936619557 modified "2023-10-14" @default.
• W2936619557 title "Surveillance for severe hand, foot, and mouth disease from 2009 to 2015 in Jiangsu province: epidemiology, etiology, and disease burden" @default.
• W2936619557 cites W1561477257 @default.
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• W2936619557 cites W1965198044 @default.
• W2936619557 cites W1982319128 @default.
• W2936619557 cites W1983384565 @default.
• W2936619557 cites W1984450481 @default.
• W2936619557 cites W1997940511 @default.
• W2936619557 cites W2004775359 @default.
• W2936619557 cites W2006840513 @default.
• W2936619557 cites W2008491616 @default.
• W2936619557 cites W2011701405 @default.
• W2936619557 cites W2013339538 @default.
• W2936619557 cites W2013518376 @default.
• W2936619557 cites W2017204494 @default.
• W2936619557 cites W2023714135 @default.
• W2936619557 cites W2029204218 @default.
• W2936619557 cites W2033494363 @default.
• W2936619557 cites W2034332937 @default.
• W2936619557 cites W2036658289 @default.
• W2936619557 cites W2039970035 @default.
• W2936619557 cites W204088460 @default.
• W2936619557 cites W2042361543 @default.
• W2936619557 cites W2043095879 @default.
• W2936619557 cites W2052808697 @default.
• W2936619557 cites W2056068865 @default.
• W2936619557 cites W2062876847 @default.
• W2936619557 cites W2063695195 @default.
• W2936619557 cites W2065423225 @default.
• W2936619557 cites W2067847940 @default.
• W2936619557 cites W2085118444 @default.
• W2936619557 cites W2094920604 @default.
• W2936619557 cites W2097706568 @default.
• W2936619557 cites W2108712394 @default.
• W2936619557 cites W2108988396 @default.
• W2936619557 cites W2110014560 @default.
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• W2936619557 cites W2113687701 @default.
• W2936619557 cites W2116742638 @default.
• W2936619557 cites W2117289855 @default.
• W2936619557 cites W2118927114 @default.
• W2936619557 cites W2123753779 @default.
• W2936619557 cites W2124063640 @default.
• W2936619557 cites W2131891726 @default.
• W2936619557 cites W2132632499 @default.
• W2936619557 cites W2133625918 @default.
• W2936619557 cites W2134683222 @default.
• W2936619557 cites W2146676231 @default.
• W2936619557 cites W2153545807 @default.
• W2936619557 cites W2153710955 @default.
• W2936619557 cites W2160435213 @default.
• W2936619557 cites W2165200955 @default.
• W2936619557 cites W2168760120 @default.
• W2936619557 cites W2169411635 @default.
• W2936619557 cites W2248519466 @default.
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• W2936619557 doi "https://doi.org/10.1186/s12879-018-3659-7" @default.
• W2936619557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6341624" @default.
• W2936619557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30669973" @default.
• W2936619557 hasPublicationYear "2019" @default.
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