FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936620722> ?p ?o ?g. }

• W2936620722 endingPage "384" @default.
• W2936620722 startingPage "370" @default.
• W2936620722 abstract "This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the estimands and estimators can be found in our companion papers. Three scenarios of increasing complexity are illustrated. The first example is a proof-of-concept trial in major depressive disorder where the estimand is chosen to support the sponsor decision on whether to continue development. The second and third examples are confirmatory trials in severe asthma and rheumatoid arthritis respectively. We discuss the intercurrent events expected during each trial and how they can be handled so as to be consistent with the study objectives. The estimands discussed in these examples are not the only acceptable choices for their respective scenarios. The intent is to illustrate the key concepts rather than focus on specific choices. Emphasis is placed on following a study development process where estimands link the study objectives with data collection and analysis in a coherent manner, thereby avoiding disconnect between objectives, estimands, and analyses." @default.
• W2936620722 created "2019-04-25" @default.
• W2936620722 creator A5000460289 @default.
• W2936620722 creator A5004200946 @default.
• W2936620722 creator A5025355536 @default.
• W2936620722 creator A5033916270 @default.
• W2936620722 creator A5040115712 @default.
• W2936620722 creator A5042304299 @default.
• W2936620722 creator A5044607777 @default.
• W2936620722 creator A5062186840 @default.
• W2936620722 creator A5066583936 @default.
• W2936620722 date "2020-01-06" @default.
• W2936620722 modified "2023-10-09" @default.
• W2936620722 title "Defining Efficacy Estimands in Clinical Trials: Examples Illustrating ICH E9(R1) Guidelines" @default.
• W2936620722 cites W1903301610 @default.
• W2936620722 cites W1975915837 @default.
• W2936620722 cites W1976127885 @default.
• W2936620722 cites W1977634030 @default.
• W2936620722 cites W1978199985 @default.
• W2936620722 cites W2003363634 @default.
• W2936620722 cites W2030962294 @default.
• W2936620722 cites W2043698528 @default.
• W2936620722 cites W2063780624 @default.
• W2936620722 cites W2073833032 @default.
• W2936620722 cites W2099334955 @default.
• W2936620722 cites W2118826874 @default.
• W2936620722 cites W2149026148 @default.
• W2936620722 cites W2153480522 @default.
• W2936620722 cites W2158058290 @default.
• W2936620722 cites W2168285948 @default.
• W2936620722 cites W2206432491 @default.
• W2936620722 cites W2295832964 @default.
• W2936620722 cites W2485563171 @default.
• W2936620722 cites W2513071688 @default.
• W2936620722 cites W2513258422 @default.
• W2936620722 doi "https://doi.org/10.1007/s43441-019-00065-7" @default.
• W2936620722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32072586" @default.
• W2936620722 hasPublicationYear "2020" @default.
• W2936620722 type Work @default.
• W2936620722 sameAs 2936620722 @default.
• W2936620722 citedByCount "23" @default.
• W2936620722 countsByYear W29366207222020 @default.
• W2936620722 countsByYear W29366207222021 @default.
• W2936620722 countsByYear W29366207222022 @default.
• W2936620722 countsByYear W29366207222023 @default.
• W2936620722 crossrefType "journal-article" @default.
• W2936620722 hasAuthorship W2936620722A5000460289 @default.
• W2936620722 hasAuthorship W2936620722A5004200946 @default.
• W2936620722 hasAuthorship W2936620722A5025355536 @default.
• W2936620722 hasAuthorship W2936620722A5033916270 @default.
• W2936620722 hasAuthorship W2936620722A5040115712 @default.
• W2936620722 hasAuthorship W2936620722A5042304299 @default.
• W2936620722 hasAuthorship W2936620722A5044607777 @default.
• W2936620722 hasAuthorship W2936620722A5062186840 @default.
• W2936620722 hasAuthorship W2936620722A5066583936 @default.
• W2936620722 hasBestOaLocation W29366207222 @default.
• W2936620722 hasConcept C104863432 @default.
• W2936620722 hasConcept C111919701 @default.
• W2936620722 hasConcept C142724271 @default.
• W2936620722 hasConcept C15744967 @default.
• W2936620722 hasConcept C162324750 @default.
• W2936620722 hasConcept C204787440 @default.
• W2936620722 hasConcept C2780454255 @default.
• W2936620722 hasConcept C41008148 @default.
• W2936620722 hasConcept C509550671 @default.
• W2936620722 hasConcept C512399662 @default.
• W2936620722 hasConcept C535046627 @default.
• W2936620722 hasConcept C539667460 @default.
• W2936620722 hasConcept C71924100 @default.
• W2936620722 hasConcept C98045186 @default.
• W2936620722 hasConceptScore W2936620722C104863432 @default.
• W2936620722 hasConceptScore W2936620722C111919701 @default.
• W2936620722 hasConceptScore W2936620722C142724271 @default.
• W2936620722 hasConceptScore W2936620722C15744967 @default.
• W2936620722 hasConceptScore W2936620722C162324750 @default.
• W2936620722 hasConceptScore W2936620722C204787440 @default.
• W2936620722 hasConceptScore W2936620722C2780454255 @default.
• W2936620722 hasConceptScore W2936620722C41008148 @default.
• W2936620722 hasConceptScore W2936620722C509550671 @default.
• W2936620722 hasConceptScore W2936620722C512399662 @default.
• W2936620722 hasConceptScore W2936620722C535046627 @default.
• W2936620722 hasConceptScore W2936620722C539667460 @default.
• W2936620722 hasConceptScore W2936620722C71924100 @default.
• W2936620722 hasConceptScore W2936620722C98045186 @default.
• W2936620722 hasIssue "2" @default.
• W2936620722 hasLocation W29366207221 @default.
• W2936620722 hasLocation W29366207222 @default.
• W2936620722 hasLocation W29366207223 @default.
• W2936620722 hasOpenAccess W2936620722 @default.
• W2936620722 hasPrimaryLocation W29366207221 @default.
• W2936620722 hasRelatedWork W1997367031 @default.
• W2936620722 hasRelatedWork W2069385463 @default.
• W2936620722 hasRelatedWork W2364311723 @default.
• W2936620722 hasRelatedWork W2364973063 @default.
• W2936620722 hasRelatedWork W2379162918 @default.
• W2936620722 hasRelatedWork W2748952813 @default.
• W2936620722 hasRelatedWork W2899084033 @default.
• W2936620722 hasRelatedWork W2985800505 @default.

• next