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- W2936682755 endingPage "511" @default.
- W2936682755 startingPage "503" @default.
- W2936682755 abstract "Abstract Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune condition that commonly causes kidney impairment and can be fatal. The key participation of B-lymphocytes as ANCA producers and neutrophils as target of these antibodies is widely described as the mechanism of endothelial damage in this disease. There has been a rising interest in the role of T-lymphocytes in AAV in recent years. Evidence is strong from animal models, and T-lymphocytes can be found infiltrating kidney tissue and other tissue sites in AAV patients. Furthermore, the different subsets of T-lymphocytes are also key players in the aberrant immune response observed in AAV. Polarization towards a predominant Th1 and Th17 response in the acute phase of the disease has been described, along with a decline in the number of T-regulatory lymphocytes, which, in turn, show functional impairment. Interactions between different T-cell subsets, and between T-cells and neutrophils and B-cells, also enhance the inflammatory response, constituting a complex network. Novel therapies targeting T-cell immunity are emerging in this scenario and may constitute an interesting alternative to conventional therapy in selected patients. This review aims to summarize the available evidence regarding T-cell imbalances and functional impairment, especially focusing on renal involvement of AAV." @default.
- W2936682755 created "2019-04-25" @default.
- W2936682755 creator A5004108111 @default.
- W2936682755 creator A5008163390 @default.
- W2936682755 creator A5016547169 @default.
- W2936682755 creator A5021545164 @default.
- W2936682755 creator A5022456652 @default.
- W2936682755 creator A5085760905 @default.
- W2936682755 date "2019-04-19" @default.
- W2936682755 modified "2023-10-12" @default.
- W2936682755 title "T-lymphocyte in ANCA-associated vasculitis: what do we know? A pathophysiological and therapeutic approach" @default.
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