FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936692586> ?p ?o ?g. }

• W2936692586 abstract "Despite major improvements in child survival rates, the number of deaths due to diarrhea remains unacceptably high. We aimed to describe diarrhea-associated mortality and evaluate risk factors for death among Mozambican children with moderate-to-severe diarrhea (MSD).Between December 2007 and November 2012, children under-five with MSD were enrolled in Manhiça district, as part of the Global Enteric Multicenter study (GEMS). Clinical, epidemiological, and socio-demographic characteristics were collected. Anthropometric measurements were performed and stool samples collected upon recruitment. A follow-up visit ~ 60 days post-enrolment was conducted and verbal autopsies performed in all death cases.Of the 916 MSD-cases analyzed; 90% (821/916) completed 60 days follow-up and 69 patients died. The case fatality rate at follow-up was 8% (69/821), and the mortality rate 10.2 (95%CI: 7.75-13.59) deaths per 1000 persons-week at risk. Nearly half of the deaths 48% (33/69) among study participants clustered within 2 weeks of the onset of diarrhea. Typical enteropathogenic Escherichia coli (typical EPEC) and Cryptosporidium were the two pathogens associated to an increased risk of death in the univariate analysis with (HR = 4.16, p = 0.0461) and (H = 2.84, p = 0.0001) respectively. Conversely, Rotavirus infection was associated to a decreased risk of death (HR = 0.52, p = 0.0198). According to the multivariate analysis, risk factors for death included co-morbidities such as malnutrition (HR = 4.13, p < 0.0001), pneumonia/lower respiratory infection (HR = 3.51, p < 0.0001) or invasive bacterial disease (IBD) (HR = 6.80, p = 0.0009), presenting on arrival with lethargy or overt unconsciousness (HR = 1.73, p = 0.0302) or wrinkled skin (HR = 1.71, p = 0.0393), and cryptosporidium infection (HR = 2.14, p = 0.0038). When restricting the analysis to those with available HIV results (n = 191, 22% of the total study sample), HIV was shown to be a significant risk factor for death (HR = 5.05, p = 0.0009). Verbal autopsies were conducted in 100% of study deaths, and highlighted diarrhea as the main underlying cause of death 39%, (27/69); followed by HIV/AIDS related deaths 29.0% (20/69) and sepsis 11.6% (8/69).Preventive strategies targeting Cryptosporidium, malnutrition and early identification and treatment of associated co-morbidities could contribute to the prevention of the majority of diarrhea associated deaths in Mozambican children." @default.
• W2936692586 created "2019-04-25" @default.
• W2936692586 creator A5007441806 @default.
• W2936692586 creator A5018831973 @default.
• W2936692586 creator A5025149327 @default.
• W2936692586 creator A5030515780 @default.
• W2936692586 creator A5040823189 @default.
• W2936692586 creator A5043650852 @default.
• W2936692586 creator A5049145301 @default.
• W2936692586 creator A5058441643 @default.
• W2936692586 creator A5081603649 @default.
• W2936692586 creator A5084619399 @default.
• W2936692586 creator A5086821007 @default.
• W2936692586 creator A5091462049 @default.
• W2936692586 date "2019-04-15" @default.
• W2936692586 modified "2023-10-14" @default.
• W2936692586 title "Risk factors for death among children 0–59 months of age with moderate-to-severe diarrhea in Manhiça district, southern Mozambique" @default.
• W2936692586 cites W1477362925 @default.
• W2936692586 cites W1631592738 @default.
• W2936692586 cites W1801074840 @default.
• W2936692586 cites W1971669360 @default.
• W2936692586 cites W1989213472 @default.
• W2936692586 cites W2003909909 @default.
• W2936692586 cites W2005551982 @default.
• W2936692586 cites W2005766930 @default.
• W2936692586 cites W2013416277 @default.
• W2936692586 cites W2023250382 @default.
• W2936692586 cites W2042034188 @default.
• W2936692586 cites W2047838794 @default.
• W2936692586 cites W2049209813 @default.
• W2936692586 cites W2061672777 @default.
• W2936692586 cites W2062500976 @default.
• W2936692586 cites W2078129874 @default.
• W2936692586 cites W2094128040 @default.
• W2936692586 cites W2099752711 @default.
• W2936692586 cites W2105526755 @default.
• W2936692586 cites W2109076969 @default.
• W2936692586 cites W2114053580 @default.
• W2936692586 cites W2120091748 @default.
• W2936692586 cites W2125065061 @default.
• W2936692586 cites W2128948174 @default.
• W2936692586 cites W2131381620 @default.
• W2936692586 cites W2139343763 @default.
• W2936692586 cites W2140317080 @default.
• W2936692586 cites W2144849019 @default.
• W2936692586 cites W2146384937 @default.
• W2936692586 cites W2146648834 @default.
• W2936692586 cites W2149647471 @default.
• W2936692586 cites W2157021828 @default.
• W2936692586 cites W2171475272 @default.
• W2936692586 cites W2191139669 @default.
• W2936692586 cites W2306447256 @default.
• W2936692586 cites W2328134362 @default.
• W2936692586 cites W2343949934 @default.
• W2936692586 cites W2399861846 @default.
• W2936692586 cites W2521607002 @default.
• W2936692586 cites W2549697535 @default.
• W2936692586 cites W2606002843 @default.
• W2936692586 cites W2620681788 @default.
• W2936692586 cites W2783891790 @default.
• W2936692586 cites W2792218416 @default.
• W2936692586 cites W2805335496 @default.
• W2936692586 cites W310820143 @default.
• W2936692586 cites W4211093840 @default.
• W2936692586 cites W852567253 @default.
• W2936692586 doi "https://doi.org/10.1186/s12879-019-3948-9" @default.
• W2936692586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6466733" @default.
• W2936692586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30987589" @default.
• W2936692586 hasPublicationYear "2019" @default.
• W2936692586 type Work @default.
• W2936692586 sameAs 2936692586 @default.
• W2936692586 citedByCount "25" @default.
• W2936692586 countsByYear W29366925862019 @default.
• W2936692586 countsByYear W29366925862021 @default.
• W2936692586 countsByYear W29366925862022 @default.
• W2936692586 countsByYear W29366925862023 @default.
• W2936692586 crossrefType "journal-article" @default.
• W2936692586 hasAuthorship W2936692586A5007441806 @default.
• W2936692586 hasAuthorship W2936692586A5018831973 @default.
• W2936692586 hasAuthorship W2936692586A5025149327 @default.
• W2936692586 hasAuthorship W2936692586A5030515780 @default.
• W2936692586 hasAuthorship W2936692586A5040823189 @default.
• W2936692586 hasAuthorship W2936692586A5043650852 @default.
• W2936692586 hasAuthorship W2936692586A5049145301 @default.
• W2936692586 hasAuthorship W2936692586A5058441643 @default.
• W2936692586 hasAuthorship W2936692586A5081603649 @default.
• W2936692586 hasAuthorship W2936692586A5084619399 @default.
• W2936692586 hasAuthorship W2936692586A5086821007 @default.
• W2936692586 hasAuthorship W2936692586A5091462049 @default.
• W2936692586 hasBestOaLocation W29366925861 @default.
• W2936692586 hasConcept C107130276 @default.
• W2936692586 hasConcept C126322002 @default.
• W2936692586 hasConcept C144301174 @default.
• W2936692586 hasConcept C179755657 @default.
• W2936692586 hasConcept C187212893 @default.
• W2936692586 hasConcept C187316915 @default.
• W2936692586 hasConcept C2777914695 @default.
• W2936692586 hasConcept C2779134260 @default.
• W2936692586 hasConcept C2779802037 @default.
• W2936692586 hasConcept C2781367151 @default.

• next