FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936697221> ?p ?o ?g. }

• W2936697221 abstract "Paenibacillus larvae, the causative agent of American foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g., with tylosin), neither of which is fully satisfactory. The search for superior means for controlling AFB has led to an increased interest in the natural relationships between the honeybee-pathogenic and mutualistic microorganisms and, in particular, the antagonistic effects of honeybee-specific lactic acid bacteria (hbs-LAB) against P. larvae These effects have been demonstrated only on individual larvae in controlled laboratory bioassays. Here we investigated whether supplemental administration of hbs-LAB had a similar beneficial effect on P. larvae infection at colony level. We compared experimentally AFB-infected colonies treated with hbs-LAB supplements to untreated and tylosin-treated colonies and recorded AFB symptoms, bacterial spore levels, and two measures of colony health. To account for the complexity of a bee colony, we focused on (Bayesian) probabilities and magnitudes of effect sizes. Tylosin reduced AFB disease symptoms but also had a negative effect on colony strength. The tylosin treatment did not, however, affect P. larvae spore levels and might therefore mask the potential for disease. hbs-LAB tended to reduce brood size in the short term but was unlikely to affect AFB symptoms or spores. These results do not contradict demonstrated antagonistic effects of hbs-LAB against P. larvae at the individual bee level but rather suggest that supplementary administration of hbs-LAB may not be the most effective way to harness these beneficial effects at the colony level.IMPORTANCE The previously demonstrated antagonistic effects of honeybee-derived bacterial microbiota on the infectivity and pathogenicity of P. larvae in laboratory bioassays have identified a possible new approach to AFB control. However, honeybee colonies are complex superorganisms where social immune defenses play a major role in resistance against disease at the colony level. Few studies have investigated the effect of beneficial microorganisms on bee diseases at the colony level. Effects observed at the individual bee level do not necessarily translate into similar effects at the colony level. This study partially fills this gap by showing that, unlike at the individual level, hbs-LAB supplements did not affect AFB symptoms at the colony level. The inference is that the mechanisms regulating the honeybee microbial dynamics within a colony are too strong to manipulate positively through supplemental feeding of live hbs-LAB and that new potential remedies identified through laboratory research have to be tested thoroughly in situ, in colonies." @default.
• W2936697221 created "2019-04-25" @default.
• W2936697221 creator A5015484054 @default.
• W2936697221 creator A5031828264 @default.
• W2936697221 creator A5047384574 @default.
• W2936697221 creator A5048707669 @default.
• W2936697221 creator A5063982834 @default.
• W2936697221 creator A5075060905 @default.
• W2936697221 date "2019-07-01" @default.
• W2936697221 modified "2023-10-18" @default.
• W2936697221 title "Honeybee-Specific Lactic Acid Bacterium Supplements Have No Effect on American Foulbrood-Infected Honeybee Colonies" @default.
• W2936697221 cites W1498752349 @default.
• W2936697221 cites W1580925114 @default.
• W2936697221 cites W1596423729 @default.
• W2936697221 cites W1890060878 @default.
• W2936697221 cites W1932011412 @default.
• W2936697221 cites W1964313820 @default.
• W2936697221 cites W1971266533 @default.
• W2936697221 cites W1979409285 @default.
• W2936697221 cites W1995811562 @default.
• W2936697221 cites W1998260381 @default.
• W2936697221 cites W2003519966 @default.
• W2936697221 cites W2007224435 @default.
• W2936697221 cites W2009704313 @default.
• W2936697221 cites W2016366315 @default.
• W2936697221 cites W2022695709 @default.
• W2936697221 cites W2036704382 @default.
• W2936697221 cites W2037259497 @default.
• W2936697221 cites W2056657539 @default.
• W2936697221 cites W2062108662 @default.
• W2936697221 cites W2063535459 @default.
• W2936697221 cites W2069024681 @default.
• W2936697221 cites W2069637953 @default.
• W2936697221 cites W2071111532 @default.
• W2936697221 cites W2102746000 @default.
• W2936697221 cites W2104551406 @default.
• W2936697221 cites W2106699965 @default.
• W2936697221 cites W2110684484 @default.
• W2936697221 cites W2130590219 @default.
• W2936697221 cites W2132479009 @default.
• W2936697221 cites W2137435665 @default.
• W2936697221 cites W2143258268 @default.
• W2936697221 cites W2143964090 @default.
• W2936697221 cites W2145274401 @default.
• W2936697221 cites W2145780927 @default.
• W2936697221 cites W2147392834 @default.
• W2936697221 cites W2163861300 @default.
• W2936697221 cites W2170027074 @default.
• W2936697221 cites W2174418805 @default.
• W2936697221 cites W2177638725 @default.
• W2936697221 cites W2318830867 @default.
• W2936697221 cites W2333341225 @default.
• W2936697221 cites W2344927143 @default.
• W2936697221 cites W2461365949 @default.
• W2936697221 cites W2514049192 @default.
• W2936697221 cites W2528403028 @default.
• W2936697221 cites W2561955273 @default.
• W2936697221 cites W2605691951 @default.
• W2936697221 cites W2714107744 @default.
• W2936697221 cites W2732061207 @default.
• W2936697221 cites W2767577579 @default.
• W2936697221 cites W2767847412 @default.
• W2936697221 cites W2770568933 @default.
• W2936697221 cites W2781796812 @default.
• W2936697221 cites W2782847137 @default.
• W2936697221 cites W2915771806 @default.
• W2936697221 cites W2930613241 @default.
• W2936697221 cites W3124625789 @default.
• W2936697221 cites W4248081888 @default.
• W2936697221 doi "https://doi.org/10.1128/aem.00606-19" @default.
• W2936697221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6581185" @default.
• W2936697221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31003985" @default.
• W2936697221 hasPublicationYear "2019" @default.
• W2936697221 type Work @default.
• W2936697221 sameAs 2936697221 @default.
• W2936697221 citedByCount "22" @default.
• W2936697221 countsByYear W29366972212019 @default.
• W2936697221 countsByYear W29366972212020 @default.
• W2936697221 countsByYear W29366972212021 @default.
• W2936697221 countsByYear W29366972212022 @default.
• W2936697221 countsByYear W29366972212023 @default.
• W2936697221 crossrefType "journal-article" @default.
• W2936697221 hasAuthorship W2936697221A5015484054 @default.
• W2936697221 hasAuthorship W2936697221A5031828264 @default.
• W2936697221 hasAuthorship W2936697221A5047384574 @default.
• W2936697221 hasAuthorship W2936697221A5048707669 @default.
• W2936697221 hasAuthorship W2936697221A5063982834 @default.
• W2936697221 hasAuthorship W2936697221A5075060905 @default.
• W2936697221 hasBestOaLocation W29366972211 @default.
• W2936697221 hasConcept C114265396 @default.
• W2936697221 hasConcept C174618031 @default.
• W2936697221 hasConcept C18903297 @default.
• W2936697221 hasConcept C21078798 @default.
• W2936697221 hasConcept C2776460866 @default.
• W2936697221 hasConcept C2777818307 @default.
• W2936697221 hasConcept C2777907900 @default.
• W2936697221 hasConcept C2780514615 @default.
• W2936697221 hasConcept C31903555 @default.
• W2936697221 hasConcept C501593827 @default.
• W2936697221 hasConcept C523546767 @default.

• next