Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936698188> ?p ?o ?g. }
- W2936698188 endingPage "1405" @default.
- W2936698188 startingPage "1390" @default.
- W2936698188 abstract "Desmogleins (Dsgs) are cadherin family adhesion molecules essential for epidermal integrity. Previous studies have shown that desmogleins associate with lipid rafts, but the significance of this association was not clear. Here, we report that the desmoglein transmembrane domain (TMD) is the primary determinant of raft association. Further, we identify a novel mutation in the DSG1 TMD (G562R) that causes severe dermatitis, multiple allergies, and metabolic wasting syndrome. Molecular modeling predicts that this G-to-R mutation shortens the DSG1 TMD, and experiments directly demonstrate that this mutation compromises both lipid raft association and desmosome incorporation. Finally, cryo-electron tomography indicates that the lipid bilayer within the desmosome is ∼10% thicker than adjacent regions of the plasma membrane. These findings suggest that differences in bilayer thickness influence the organization of adhesion molecules within the epithelial plasma membrane, with cadherin TMDs recruited to the desmosome via the establishment of a specialized mesoscale lipid raft-like membrane domain." @default.
- W2936698188 created "2019-04-25" @default.
- W2936698188 creator A5003185407 @default.
- W2936698188 creator A5003522233 @default.
- W2936698188 creator A5004788764 @default.
- W2936698188 creator A5010432302 @default.
- W2936698188 creator A5016886169 @default.
- W2936698188 creator A5023094137 @default.
- W2936698188 creator A5023276306 @default.
- W2936698188 creator A5027175857 @default.
- W2936698188 creator A5036663423 @default.
- W2936698188 creator A5044698632 @default.
- W2936698188 creator A5046385267 @default.
- W2936698188 creator A5047797726 @default.
- W2936698188 creator A5053520157 @default.
- W2936698188 creator A5058739417 @default.
- W2936698188 creator A5073839222 @default.
- W2936698188 creator A5075752283 @default.
- W2936698188 creator A5078821139 @default.
- W2936698188 creator A5088606060 @default.
- W2936698188 date "2019-06-01" @default.
- W2936698188 modified "2023-10-12" @default.
- W2936698188 title "The desmosome is a mesoscale lipid raft–like membrane domain" @default.
- W2936698188 cites W1175815497 @default.
- W2936698188 cites W1482735918 @default.
- W2936698188 cites W1491637328 @default.
- W2936698188 cites W1576938023 @default.
- W2936698188 cites W158997302 @default.
- W2936698188 cites W1602264889 @default.
- W2936698188 cites W1770349940 @default.
- W2936698188 cites W1912672559 @default.
- W2936698188 cites W195691297 @default.
- W2936698188 cites W1971557848 @default.
- W2936698188 cites W1978543959 @default.
- W2936698188 cites W1983025328 @default.
- W2936698188 cites W1989855778 @default.
- W2936698188 cites W1990248325 @default.
- W2936698188 cites W1991526125 @default.
- W2936698188 cites W1993229863 @default.
- W2936698188 cites W1993409834 @default.
- W2936698188 cites W1993556675 @default.
- W2936698188 cites W1994984215 @default.
- W2936698188 cites W1999077168 @default.
- W2936698188 cites W2001049251 @default.
- W2936698188 cites W2010315663 @default.
- W2936698188 cites W2010922273 @default.
- W2936698188 cites W2014578140 @default.
- W2936698188 cites W2016343967 @default.
- W2936698188 cites W2021867116 @default.
- W2936698188 cites W2021882008 @default.
- W2936698188 cites W2025289160 @default.
- W2936698188 cites W2027327211 @default.
- W2936698188 cites W2028745367 @default.
- W2936698188 cites W2029131812 @default.
- W2936698188 cites W2037385055 @default.
- W2936698188 cites W2039542151 @default.
- W2936698188 cites W2046973476 @default.
- W2936698188 cites W2052920039 @default.
- W2936698188 cites W2054550914 @default.
- W2936698188 cites W2059807927 @default.
- W2936698188 cites W2065886456 @default.
- W2936698188 cites W2079725368 @default.
- W2936698188 cites W2080494149 @default.
- W2936698188 cites W2084385850 @default.
- W2936698188 cites W2084868940 @default.
- W2936698188 cites W2086576792 @default.
- W2936698188 cites W2087208747 @default.
- W2936698188 cites W2089787507 @default.
- W2936698188 cites W2090725540 @default.
- W2936698188 cites W2092124228 @default.
- W2936698188 cites W2098056931 @default.
- W2936698188 cites W2102399834 @default.
- W2936698188 cites W2103292783 @default.
- W2936698188 cites W2104549677 @default.
- W2936698188 cites W2107375753 @default.
- W2936698188 cites W2108598406 @default.
- W2936698188 cites W2108838261 @default.
- W2936698188 cites W2110916958 @default.
- W2936698188 cites W2111724662 @default.
- W2936698188 cites W2115167726 @default.
- W2936698188 cites W2125878895 @default.
- W2936698188 cites W2128582408 @default.
- W2936698188 cites W2137324750 @default.
- W2936698188 cites W2146578303 @default.
- W2936698188 cites W2148618853 @default.
- W2936698188 cites W2154295604 @default.
- W2936698188 cites W2158603948 @default.
- W2936698188 cites W2159918368 @default.
- W2936698188 cites W2160165571 @default.
- W2936698188 cites W2164199975 @default.
- W2936698188 cites W2167774643 @default.
- W2936698188 cites W2174135184 @default.
- W2936698188 cites W2256090482 @default.
- W2936698188 cites W2278487942 @default.
- W2936698188 cites W2319428081 @default.
- W2936698188 cites W2345057386 @default.
- W2936698188 cites W2345640761 @default.
- W2936698188 cites W2409520759 @default.