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• W2936698466 abstract "‘Cara Cara’ is a red orange ( Citrus sinensis (L.) Osbeck) variety originally from Venezuela characterized by a significantly higher and diversified carotenoid content including higher-concentration lycopene, all -E- β -carotene, phytoene, and other carotenoids when compared with the carotenoid profile of its isogenic blond counterpart ‘Bahia’, also known as Washington navel. The exceptionally high carotenoid content of ‘Cara Cara’ is of special interest due to its neuroprotective potential. Here, we used the nematode Caenorhabditis elegans to analyze the antioxidant effect and the protection against β -amyloid-induced toxicity of pasteurized orange juice (POJ) obtained from ‘Cara Cara’ and compare to that from ‘Bahia’. POJ treatment reduced the endogenous ROS levels and increased the worm’s survival rate under normal and oxidative stress conditions. POJ treatment also upregulated the expression of antioxidant ( gcs-1 , gst-4 , and sod-3 ) and chaperonin ( hsp-16.2 ) genes. Remarkably, ROS reduction, gene expression activation, oxidative stress resistance, and longevity extension were significantly increased in the animals treated with ‘Cara Cara’ orange juice compared to animals treated with ‘Bahia’ orange juice. Furthermore, the body paralysis induced by β -amyloid peptide was delayed by both POJs but the mean paralysis time for the worms treated with ‘Cara Cara’ orange juice was significantly higher compared to ‘Bahia’ orange juice. Our mechanistic studies indicated that POJ-reduced ROS levels are primarily a result of the direct scavenging action of natural compounds available in the orange juice. Moreover, POJ-induced gst-4::GFP expression and –increased stress resistance was dependent of the SKN-1/Nrf2 transcription factor. Finally, the transcription factors SKN-1, DAF-16, and HSF-1 were required for the POJ-mediated protective effect against A β toxicity. Collectively, these results suggest that orange juice from ‘Cara Cara’ induced a stronger response against oxidative stress and β -amyloid toxicity compared to orange juice from ‘Bahia’ possibly due to its higher carotenoid content." @default.
• W2936698466 created "2019-04-25" @default.
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• W2936698466 date "2019-04-18" @default.
• W2936698466 modified "2023-09-26" @default.
• W2936698466 title "Pasteurized Orange Juice Rich in Carotenoids Protects<i>Caenorhabditis elegans</i>against Oxidative Stress and<i>β</i>-Amyloid Toxicity through Direct and Indirect Mechanisms" @default.
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• W2936698466 doi "https://doi.org/10.1155/2019/5046280" @default.
• W2936698466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6501168" @default.
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