Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936704425> ?p ?o ?g. }
- W2936704425 endingPage "533" @default.
- W2936704425 startingPage "527" @default.
- W2936704425 abstract "Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded products or pathogen activities often enables the activation of a subset of caspases. In most cases, the cytosolic surveillance pathways are coupled to activation of caspase-1 via canonical inflammasome complexes. A related set of caspases, caspase-11 in rodents and caspase-4 and caspase-5 in humans, monitors the cytosol for bacterial lipopolysaccharide (LPS). Direct activation of caspase-11, caspase-4 and caspase-5 by intracellular LPS elicits the lytic cell death called 'pyroptosis', which occurs in multiple cell types. The pyroptosis is executed by the pore-forming protein GSDMD, which is activated by cleavage mediated by caspase-11, caspase-4 or caspase-5. In monocytes, formation of GSDMD pores can induce activation of the NLRP3 inflammasome for maturation of the cytokines IL-1β and IL-18. Caspase-11-mediated pyroptosis in response to cytosolic LPS is critical for antibacterial defense and septic shock. Here we review the emerging literature on the sensing of cytosolic LPS and its regulation and pathophysiological functions." @default.
- W2936704425 created "2019-04-25" @default.
- W2936704425 creator A5013385995 @default.
- W2936704425 creator A5013760778 @default.
- W2936704425 creator A5041938409 @default.
- W2936704425 date "2019-04-08" @default.
- W2936704425 modified "2023-10-14" @default.
- W2936704425 title "Innate immunity to intracellular LPS" @default.
- W2936704425 cites W1529674879 @default.
- W2936704425 cites W1536607091 @default.
- W2936704425 cites W1630899685 @default.
- W2936704425 cites W1848353047 @default.
- W2936704425 cites W1858567345 @default.
- W2936704425 cites W1864325817 @default.
- W2936704425 cites W1882905539 @default.
- W2936704425 cites W1904683780 @default.
- W2936704425 cites W1963676049 @default.
- W2936704425 cites W1970837608 @default.
- W2936704425 cites W1973288627 @default.
- W2936704425 cites W1973723338 @default.
- W2936704425 cites W1979318608 @default.
- W2936704425 cites W1984035213 @default.
- W2936704425 cites W1984632540 @default.
- W2936704425 cites W2007747853 @default.
- W2936704425 cites W2008261126 @default.
- W2936704425 cites W2014602273 @default.
- W2936704425 cites W2023368253 @default.
- W2936704425 cites W2024591203 @default.
- W2936704425 cites W2029965087 @default.
- W2936704425 cites W2042433863 @default.
- W2936704425 cites W2055727949 @default.
- W2936704425 cites W2060122053 @default.
- W2936704425 cites W2068619092 @default.
- W2936704425 cites W2075611712 @default.
- W2936704425 cites W2080827095 @default.
- W2936704425 cites W2083859580 @default.
- W2936704425 cites W2084708403 @default.
- W2936704425 cites W2087470992 @default.
- W2936704425 cites W2087616650 @default.
- W2936704425 cites W2090165838 @default.
- W2936704425 cites W2105263387 @default.
- W2936704425 cites W2107387055 @default.
- W2936704425 cites W2111951615 @default.
- W2936704425 cites W2127934565 @default.
- W2936704425 cites W2143102054 @default.
- W2936704425 cites W2147627101 @default.
- W2936704425 cites W2149605526 @default.
- W2936704425 cites W2171487873 @default.
- W2936704425 cites W2175794645 @default.
- W2936704425 cites W2178911832 @default.
- W2936704425 cites W2340046691 @default.
- W2936704425 cites W2341959167 @default.
- W2936704425 cites W2345407464 @default.
- W2936704425 cites W2373811009 @default.
- W2936704425 cites W2418806051 @default.
- W2936704425 cites W2431987552 @default.
- W2936704425 cites W2461756806 @default.
- W2936704425 cites W2461915818 @default.
- W2936704425 cites W2462773201 @default.
- W2936704425 cites W2511127858 @default.
- W2936704425 cites W2518931467 @default.
- W2936704425 cites W2524431814 @default.
- W2936704425 cites W2528617117 @default.
- W2936704425 cites W2560541542 @default.
- W2936704425 cites W2592650543 @default.
- W2936704425 cites W2608687752 @default.
- W2936704425 cites W2610420640 @default.
- W2936704425 cites W2739893541 @default.
- W2936704425 cites W2746153521 @default.
- W2936704425 cites W2754876699 @default.
- W2936704425 cites W2755796574 @default.
- W2936704425 cites W2761436821 @default.
- W2936704425 cites W2761551010 @default.
- W2936704425 cites W2762648910 @default.
- W2936704425 cites W2762751213 @default.
- W2936704425 cites W2763425528 @default.
- W2936704425 cites W2763785504 @default.
- W2936704425 cites W2768102094 @default.
- W2936704425 cites W2779886179 @default.
- W2936704425 cites W2783543761 @default.
- W2936704425 cites W2785555044 @default.
- W2936704425 cites W2792819567 @default.
- W2936704425 cites W2794112735 @default.
- W2936704425 cites W2802099741 @default.
- W2936704425 cites W2802300493 @default.
- W2936704425 cites W2804618431 @default.
- W2936704425 cites W2804771306 @default.
- W2936704425 cites W2807745964 @default.
- W2936704425 cites W2808965517 @default.
- W2936704425 cites W2815732114 @default.
- W2936704425 cites W2883149324 @default.
- W2936704425 cites W2884895413 @default.
- W2936704425 cites W2887504899 @default.
- W2936704425 cites W2888168693 @default.
- W2936704425 cites W2888339623 @default.
- W2936704425 cites W2896781864 @default.
- W2936704425 cites W2898968875 @default.
- W2936704425 cites W2899591453 @default.