Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936704591> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2936704591 endingPage "68" @default.
- W2936704591 startingPage "63" @default.
- W2936704591 abstract "The Three Rs — Reduction, Replacement and Refinement — which were first proposed in 1959 by Russell and Burch, have become widely accepted principles in the governance of humane animal research. However, there is substantial variation in the ways in which different countries document the numbers and types of research animals used, making it difficult to determine how effectively the Three Rs are being implemented. Here, we provide the first data illustrating worldwide trends in animal use for research purposes. To document global trends in animal use, we sampled 2691 articles from 24 countries, published between 1983 and 2007, in four scientific journals. We show that the percentage of articles reporting animal use has risen in the past 15 years. The rising popularity of genetic modification methods has contributed to this trend: reported genetically-modified animal use has more than doubled since 1997. We also show that mice are the most commonly-used species for genetic modification, and that, even in 2007, relatively inefficient random integration methods were still widely used to achieve genetic modification. These results illustrate shortcomings in the effort to implement the Three Rs in animal research." @default.
- W2936704591 created "2019-04-25" @default.
- W2936704591 creator A5001126876 @default.
- W2936704591 creator A5038650047 @default.
- W2936704591 creator A5087846645 @default.
- W2936704591 date "2009-02-01" @default.
- W2936704591 modified "2023-10-16" @default.
- W2936704591 title "Worldwide Trends in the Use of Animals in Research: The Contribution of Genetically-modified Animal Models" @default.
- W2936704591 cites W124881219 @default.
- W2936704591 cites W1968283357 @default.
- W2936704591 cites W1984592727 @default.
- W2936704591 cites W2044830938 @default.
- W2936704591 cites W2054811612 @default.
- W2936704591 cites W2105482499 @default.
- W2936704591 cites W2111292203 @default.
- W2936704591 cites W2118327852 @default.
- W2936704591 cites W2125155632 @default.
- W2936704591 cites W2165832884 @default.
- W2936704591 cites W2170729559 @default.
- W2936704591 cites W2397455915 @default.
- W2936704591 cites W2399947190 @default.
- W2936704591 cites W2427968434 @default.
- W2936704591 cites W2569147316 @default.
- W2936704591 cites W4318472094 @default.
- W2936704591 cites W68759660 @default.
- W2936704591 doi "https://doi.org/10.1177/026119290903700109" @default.
- W2936704591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19292576" @default.
- W2936704591 hasPublicationYear "2009" @default.
- W2936704591 type Work @default.
- W2936704591 sameAs 2936704591 @default.
- W2936704591 citedByCount "29" @default.
- W2936704591 countsByYear W29367045912012 @default.
- W2936704591 countsByYear W29367045912013 @default.
- W2936704591 countsByYear W29367045912014 @default.
- W2936704591 countsByYear W29367045912015 @default.
- W2936704591 countsByYear W29367045912016 @default.
- W2936704591 countsByYear W29367045912017 @default.
- W2936704591 countsByYear W29367045912018 @default.
- W2936704591 countsByYear W29367045912019 @default.
- W2936704591 countsByYear W29367045912020 @default.
- W2936704591 countsByYear W29367045912022 @default.
- W2936704591 countsByYear W29367045912023 @default.
- W2936704591 crossrefType "journal-article" @default.
- W2936704591 hasAuthorship W2936704591A5001126876 @default.
- W2936704591 hasAuthorship W2936704591A5038650047 @default.
- W2936704591 hasAuthorship W2936704591A5087846645 @default.
- W2936704591 hasBestOaLocation W29367045911 @default.
- W2936704591 hasConcept C134018914 @default.
- W2936704591 hasConcept C150903083 @default.
- W2936704591 hasConcept C17744445 @default.
- W2936704591 hasConcept C199539241 @default.
- W2936704591 hasConcept C2778117688 @default.
- W2936704591 hasConcept C2780586970 @default.
- W2936704591 hasConcept C2993056352 @default.
- W2936704591 hasConcept C3018803906 @default.
- W2936704591 hasConcept C78458016 @default.
- W2936704591 hasConcept C86803240 @default.
- W2936704591 hasConcept C90856448 @default.
- W2936704591 hasConceptScore W2936704591C134018914 @default.
- W2936704591 hasConceptScore W2936704591C150903083 @default.
- W2936704591 hasConceptScore W2936704591C17744445 @default.
- W2936704591 hasConceptScore W2936704591C199539241 @default.
- W2936704591 hasConceptScore W2936704591C2778117688 @default.
- W2936704591 hasConceptScore W2936704591C2780586970 @default.
- W2936704591 hasConceptScore W2936704591C2993056352 @default.
- W2936704591 hasConceptScore W2936704591C3018803906 @default.
- W2936704591 hasConceptScore W2936704591C78458016 @default.
- W2936704591 hasConceptScore W2936704591C86803240 @default.
- W2936704591 hasConceptScore W2936704591C90856448 @default.
- W2936704591 hasIssue "1" @default.
- W2936704591 hasLocation W29367045911 @default.
- W2936704591 hasLocation W29367045912 @default.
- W2936704591 hasOpenAccess W2936704591 @default.
- W2936704591 hasPrimaryLocation W29367045911 @default.
- W2936704591 hasRelatedWork W183663103 @default.
- W2936704591 hasRelatedWork W2093931133 @default.
- W2936704591 hasRelatedWork W2351183322 @default.
- W2936704591 hasRelatedWork W2358626778 @default.
- W2936704591 hasRelatedWork W2395847847 @default.
- W2936704591 hasRelatedWork W2408202004 @default.
- W2936704591 hasRelatedWork W2581180521 @default.
- W2936704591 hasRelatedWork W2889343864 @default.
- W2936704591 hasRelatedWork W4236040792 @default.
- W2936704591 hasRelatedWork W4254829318 @default.
- W2936704591 hasVolume "37" @default.
- W2936704591 isParatext "false" @default.
- W2936704591 isRetracted "false" @default.
- W2936704591 magId "2936704591" @default.
- W2936704591 workType "article" @default.